Pkn1 - protein kinase N1 Gene

Also Known as DBK; Pkn; PAK1; PRK1; Stk3; Prkcl1; F730027O18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 320795

Summary

Enables protein kinase activity. Acts upstream of or within several processes, including negative regulation of B cell proliferation; regulation of germinal center formation; and spleen development. Located in cytoplasmic vesicle. Is expressed in several structures, including brown fat; genitourinary system; gut; nervous system; and vascular system. Orthologous to human PKN1 (protein kinase N1). [provided by Alliance of Genome Resources, Apr 2022]

Pkn1 Products (2)

mRNA Protein Name
NM_001199593.1 NP_001186522.1 serine/threonine-protein kinase N1 isoform 1
NM_177262.4 NP_796236.2 serine/threonine-protein kinase N1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11054541 MGI
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
12783890 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell apoptotic process IMP
IMP: Inferred from mutant phenotype
23223530 MGI
acts upstream of or within B cell homeostasis IMP
IMP: Inferred from mutant phenotype
23223530 MGI
acts upstream of or within hyperosmotic response IDA
IDA: Inferred from direct assay
12783890 MGI
acts upstream of or within negative regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
23223530 MGI
acts upstream of or within negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
23223530 MGI
acts upstream of or within negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
23223530 MGI
acts upstream of or within regulation of germinal center formation IMP
IMP: Inferred from mutant phenotype
23223530 MGI
acts upstream of or within regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
23223530 MGI
acts upstream of or within renal system process IMP
IMP: Inferred from mutant phenotype
23223530 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
23223530 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12783890 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
12783890 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase N1

  • protein kinase C-like 1

  • protein kinase C-like PKN

  • protein-kinase C-related kinase 1

  • serine-threonine protein kinase N

  • serine/threonine kinase 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145899 PKN1/2-IN-1 Inhibitor 99.92% Unkown
HY-RS10606 PKN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19934 Pkn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26436 Pkn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pkn1 NCBI NCBI:5585