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HPCAL1 - hippocalcin like 1 Gene

Also Known as BDR1; HLP2; VILIP-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3241

About HPCAL1

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:10,302,904-10,427,604 (from NCBI)

This gene has 8 transcripts (splice variants), 216 orthologues and 14 paralogues. Ubiquitous expression in lung (RPKM 11.7), small intestine (RPKM 9.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012]

HPCAL1 Products (5)

mRNA	Protein	Name
NM_001258357.2	NP_001245286.1	hippocalcin-like protein 1
NM_001258358.2	NP_001245287.1	hippocalcin-like protein 1
NM_001258359.2	NP_001245288.1	hippocalcin-like protein 1
NM_002149.4	NP_002140.2	hippocalcin-like protein 1
NM_134421.3	NP_602293.1	hippocalcin-like protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HPCAL1 Protein Structure

EF-hand_7

0
100
193 a.a.

Protein Preferred Names	Protein Names
hippocalcin-like protein 1	calcium-binding protein BDR-1

HPCAL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HPCAL1	P37235	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	HPCAL1	P37235	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	HPCAL1	P37235	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	HPCAL1	P37235	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	32296183
Intra	HPCAL1	P37235	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	HPCAL1	P37235	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	HPCAL1	P37235	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	25416956
Intra	HPCAL1	P37235	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	HPCAL1	P37235	COLGALT2	Homo sapiens	Q8IYK4	Validated Y2H	32296183
Intra	HPCAL1	P37235	YARS1	Homo sapiens	P54577	Y2H Pooling	32814053
Intra	HPCAL1	P37235	YARS1	Homo sapiens	P54577	Validated Y2H	32814053
Intra	HPCAL1	P37235	YARS1	Homo sapiens	P54577	Y2H Array	32814053
Intra	HPCAL1	P37235	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	HPCAL1	P37235	VWC2	Homo sapiens	Q2TAL6	Validated Y2H	32296183
Intra	HPCAL1	P37235	VWC2	Homo sapiens	Q2TAL6	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	VWC2	Homo sapiens	Q2TAL6	Y2H Array	32296183
Intra	HPCAL1	P37235	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	HPCAL1	P37235	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	HPCAL1	P37235	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	KRTAP17-1	Homo sapiens	Q9BYP8	Validated Y2H	32296183
Intra	HPCAL1	P37235	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
Intra	HPCAL1	P37235	C19orf44	Homo sapiens	Q9H6X5-2	Validated Y2H	32296183
Intra	HPCAL1	P37235	GATA5	Homo sapiens	Q9BWX5	Validated Y2H	32296183
Intra	HPCAL1	P37235	NBL1	Homo sapiens	P41271-2	Validated Y2H	32296183
Intra	HPCAL1	P37235	PLAAT2	Homo sapiens	Q9NWW9	Validated Y2H	32296183
Intra	HPCAL1	P37235	CREM	Homo sapiens	Q03060-25	Validated Y2H	32296183
Intra	HPCAL1	P37235	CREM	Homo sapiens	Q03060-25	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	CREM	Homo sapiens	Q03060-25	Y2H Array	32296183
Intra	HPCAL1	P37235	TPSG1	Homo sapiens	Q9NRR2	Validated Y2H	32296183
Intra	HPCAL1	P37235	AMOT	Homo sapiens	A2BDD9	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	AMOT	Homo sapiens	A2BDD9	Y2H Array	32296183
Intra	HPCAL1	P37235	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	HPCAL1	P37235	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Array	32296183
Intra	HPCAL1	P37235	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Prey Pooling	25416956
Intra	HPCAL1	P37235	C1QTNF2	Homo sapiens	Q9BXJ5	Validated Y2H	25416956
Intra	HPCAL1	P37235	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	C1QTNF2	Homo sapiens	Q9BXJ5	Validated Y2H	32296183
Intra	HPCAL1	P37235	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Array	25416956
Intra	HPCAL1	P37235	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	HPCAL1	P37235	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	HPCAL1	P37235	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	HPCAL1	P37235	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	HPCAL1	P37235	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	HPCAL1	P37235	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Cross	HPCAL1	P37235	tir	Escherichia coli O157:H7	Q7DB77	Lumier	25519916
Cross	HPCAL1	P37235	tir	Escherichia coli O157:H7	Q7DB77	Y2H	25519916
Intra	HPCAL1	P37235	MYDGF	Homo sapiens	Q969H8	Validated Y2H	32296183
Intra	HPCAL1	P37235	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	HPCAL1	P37235	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	HPCAL1	P37235	LITAF	Homo sapiens	Q99732	Validated Y2H	32296183
Intra	HPCAL1	P37235	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	HPCAL1	P37235	DTX2	Homo sapiens	Q86UW9	Y2H Array	32296183
Intra	HPCAL1	P37235	DTX2	Homo sapiens	Q86UW9	Y2H Pooling	16189514
Intra	HPCAL1	P37235	HMG20A	Homo sapiens	Q9NP66	Y2H Pooling	16189514
Intra	HPCAL1	P37235	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	25416956
Intra	HPCAL1	P37235	EFEMP2	Homo sapiens	O95967	Y2H Prey Pooling	32296183
Intra	HPCAL1	P37235	EFEMP2	Homo sapiens	O95967	Y2H Array	32296183
Intra	HPCAL1	P37235	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	HPCAL1	P37235	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	HPCAL1	P37235	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	HPCAL1	P37235	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	HPCAL1	P37235	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	HPCAL1	P37235	EPHB3	Homo sapiens	P54753	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HPCAL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70346	HLP2/HPCAL1 Protein, Human (His)	P37235 (M1-F193)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-177554	KB05yne		99.97%	Unkown
HY-185414	KB05-Biotin		/	Unkown
HY-RS06334	HPCAL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19260	Hpcal1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25749	Hpcal1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HPCAL1	VGNC	VGNC:67636
Macaca mulatta	HPCAL1	VGNC	VGNC:73510
Rattus norvegicus	HPCAL1	RGD	RGD:708375
Canis familiaris	HPCAL1	VGNC	VGNC:41768
Bos taurus	HPCAL1	VGNC	VGNC:29937
Mus musculus	HPCAL1	MGD	MGI:1855689
Others	HPCAL1	NCBI