PLAAT2 - phospholipase A and acyltransferase 2 Gene

Also Known as HRASLS2; PLAAT-2; PLA1/2-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54979

Summary

The protein encoded by this gene has both Phospholipase and Acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016]
Biased expression in duodenum (RPKM 16.4), small intestine (RPKM 9.9) and 3 other tissues.

PLAAT2 Products (1)

mRNA Protein Name
NM_017878.2 NP_060348.1 phospholipase A and acyltransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables N-acyltransferase activity IDA
IDA: Inferred from direct assay
22825852 GOA
enables phospholipase A1 activity IDA
IDA: Inferred from direct assay
22825852 GOA
enables phospholipase A2 activity IDA
IDA: Inferred from direct assay
22825852 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in N-acylphosphatidylethanolamine metabolic process IDA
IDA: Inferred from direct assay
22825852 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAAT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLAAT2 Q9NWW9 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
PLAAT2 Q9NWW9 HPCAL1 Homo sapiens P37235
Y2H Prey Pooling
32296183
Intra
PLAAT2 Q9NWW9 HPCAL1 Homo sapiens P37235
Y2H Array
32296183
Intra
PLAAT2 Q9NWW9 NCALD Homo sapiens P61601
Y2H Prey Pooling
32296183
Intra
PLAAT2 Q9NWW9 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
PLAAT2 Q9NWW9 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
PLAAT2 Q9NWW9 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10637 PLAAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10638 PLAAT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10639 PLAAT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown