Cdc6 - cell division cycle 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360621

Summary

Predicted to enable DNA replication origin binding activity; chromatin binding activity; and kinase binding activity. Involved in cellular response to peptide hormone stimulus; positive regulation of cyclin-dependent protein serine/threonine kinase activity; and positive regulation of fibroblast proliferation. Predicted to be located in several cellular components, including intercellular bridge; nucleoplasm; and spindle. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Apr 2022]

Cdc6 Products (1)

mRNA Protein Name
NM_001108298.1 NP_001101768.1 cell division control protein 6 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18356301 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
12063292 RGD
involved in cellular response to vasopressin IEP
IEP: Inferred from expression pattern
12063292 RGD
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
22223646 RGD
involved in positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
22223646 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cell division control protein 6 homolog

  • cell division cycle 6 homolog

Cdc6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cdc6 D3ZRK7 Skp1 Rattus norvegicus Q6PEC4
Anti Bait CoIP
18356301
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-11001 PHA-793887 99.25% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02308 CDC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-11001A PHA-793887 hydrochloride / Unkown
HY-118273 IPS-05002 Inhibitor / Unkown
HY-RS19310 Cdc6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25801 Cdc6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdc6 NCBI NCBI:990