Skp1 - S-phase kinase-associated protein 1 Gene

Also Known as Skp1a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287280

Summary

Predicted to enable several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin protein Ligase activity; and protein ubiquitination. Predicted to act upstream of or within protein K48-linked ubiquitination and protein monoubiquitination. Predicted to be located in centrosome and cytosol. Predicted to be part of Cul7-RING ubiquitin Ligase complex and SCF ubiquitin Ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Skp1 Products (1)

mRNA Protein Name
NM_001007608.2 NP_001007609.1 S-phase kinase-associated protein 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18356301 RGD
Cellular Component GO Annotation Evidence References Source
located in gap junction IDA
IDA: Inferred from direct assay
12117534 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

S-phase kinase-associated protein 1

  • RNA polymerase II elongation factor-like protein OCP2

  • S-phase kinase-associated protein 1A

  • cyclin A/CDK2-associated p19

  • cyclin-A/CDK2-associated protein p19

  • organ of Corti protein 2

  • p19A

  • p19skp1

Skp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Skp1 Q6PEC4 Ccna2 Rattus norvegicus G3V802
Anti Bait CoIP
18356301
Intra
Skp1 Q6PEC4 Ccne1 Rattus norvegicus P39949
Anti Bait CoIP
18356301
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100237 SZL P1-41 99.07% Unkown
HY-10949 SMER3 Inhibitor 98.33% Unkown
HY-RS12973 SKP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162240 SJH1-51B Degrader / Unkown
HY-163019 EN884 Degrader / Unkown
HY-P11020 p27 Analogue CP2 Inhibitor / Unkown
HY-RS17896 Skp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24365 Skp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Skp1 NCBI NCBI:6500