Pck1 - phosphoenolpyruvate carboxykinase 1 Gene

Also Known as GTP; PCK; Pepck; PEPCK-C; RATPEPCK

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362282

Summary

Enables several functions, including guanyl ribonucleotide binding activity; manganese ion binding activity; and nucleoside diphosphate kinase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to hexose stimulus; and cellular response to organonitrogen compound. Located in cytoplasm. Used to study type 2 diabetes mellitus. Biomarker of non-alcoholic steatohepatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pck1 Products (1)

mRNA Protein Name
NM_198780.3 NP_942075.1 phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
16125296 RGD
enables GTP binding IDA
IDA: Inferred from direct assay
17685635 RGD
enables carboxylic acid binding IDA
IDA: Inferred from direct assay
17685635 RGD
enables manganese ion binding IDA
IDA: Inferred from direct assay
17685635 RGD
enables nucleoside diphosphate kinase activity EXP
EXP: Inferred from Experiment
1383219 RGD
enables phosphoenolpyruvate carboxykinase (GTP) activity IDA
IDA: Inferred from direct assay
4186849 RGD
enables phosphoenolpyruvate carboxykinase activity IDA
IDA: Inferred from direct assay
4303362 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular hyperosmotic response IEP
IEP: Inferred from expression pattern
9530152 RGD
involved in cellular hyperosmotic salinity response IEP
IEP: Inferred from expression pattern
9530152 RGD
involved in cellular hypotonic response IEP
IEP: Inferred from expression pattern
9530152 RGD
involved in cellular hypotonic salinity response IEP
IEP: Inferred from expression pattern
9530152 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
9530152 RGD
involved in cellular response to fructose stimulus IEP
IEP: Inferred from expression pattern
21212096 RGD
involved in cellular response to glucagon stimulus IEP
IEP: Inferred from expression pattern
18335579 RGD
involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
30193097 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
24177414 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
9530152 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
18335579 RGD
involved in cellular response to phorbol 13-acetate 12-myristate IEP
IEP: Inferred from expression pattern
9530152 RGD
involved in cellular response to raffinose IEP
IEP: Inferred from expression pattern
9530152 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
21519922 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
18335579 RGD
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
4186849 RGD
involved in glucose homeostasis IDA
IDA: Inferred from direct assay
4186849 RGD
involved in glucose metabolic process IMP
IMP: Inferred from mutant phenotype
18055057 RGD
involved in glycerol biosynthetic process from pyruvate IDA
IDA: Inferred from direct assay
4186849 RGD
involved in oxaloacetate metabolic process IDA
IDA: Inferred from direct assay
4303362 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
16458327 RGD
involved in response to interleukin-6 IEP
IEP: Inferred from expression pattern
17805558 RGD
involved in response to lipid IEP
IEP: Inferred from expression pattern
21486814 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19268478 RGD
involved in response to methionine IEP
IEP: Inferred from expression pattern
23052097 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
23307605 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
4186849 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphoenolpyruvate carboxykinase, cytosolic [GTP]

  • phosphoenolpyruvate carboxykinase (GTP)

  • phosphoenolpyruvate carboxykinase 1 (soluble)

  • phosphoenolpyruvate carboxykinase 1, cytosolic

  • phosphoenolpyruvate carboxykinase, cytosolic (GTP)

  • phosphoenolpyruvate carboxylase

  • serine-protein kinase PCK1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116688 2-Hydroxy-4-(methylthio)butyric acid 88.0% Unkown
HY-N2368 Arecaidine 99.63% Unkown
HY-175266 MI1013 99.10% Unkown
HY-RS10152 PCK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17590 Pck1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24050 Pck1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pck1 NCBI NCBI:5105