USP50 - ubiquitin specific peptidase 50 Gene

Homo sapiens

Gene ID: 373509 | Gene type: protein coding

About USP50

This gene has 11 transcripts (splice variants), 172 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 3.5), bone marrow (RPKM 2.9) and 25 other tissues.

Summary

Enables ubiquitin-like protein-specific protease activity. Acts upstream of or within several processes, including nuclear speck organization; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of macromolecule metabolic process. Predicted to be active in several cellular components, including dendritic spine; midbody; and postsynaptic density. Predicted to be extrinsic component of endosome membrane and extrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

USP50 Products(1)

mRNA	Protein	Name
NM_203494.5	NP_987090.2	inactive ubiquitin carboxyl-terminal hydrolase 50

USP50 Protein Structure

UCH

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

inactive ubiquitin carboxyl-terminal hydrolase 50

inactive ubiquitin-specific peptidase 50

Related Diseases

Diseases

Alias

Spondyloarthropathy 1

Ankylosing Spondylitis	Spondyloarthropathy, Susceptibility To, 1
SPDA1	Marie-Strumpell Spondylitis
Bechterew Syndrome	Spa
Spondylarthritis Ankylopoietica	Reiter Syndrome
Ankylosing Spondylitis, Susceptibility To	Bekhterev Syndrome
Bekhterev'S Disease	Marie-Strumpell Disease
Axial Spondylarthritis	Bechterew Disease
Marie-Struempell Disease	Spondylitis Ankylopoietica
Spondyloarthritis	Spondyloarthritis Ankylopoietica
Spas	Ankylosing Spondylarthritis
Psoriatic Arthritis	Reactive Arthritis
Rheumatoid Spondylitis	Spondylitis Ankylosans
Spondylitis Ankylosing	Spondylitis, Ankylosing
Spondylarthropathies	Arthritis, Psoriatic
Arthritis, Reactive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15562	USP50 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	USP50	VGNC	VGNC:55016
Rattus norvegicus	USP50	RGD	RGD:1564751
Bos taurus	USP50	VGNC	VGNC:52848
Felis catus	USP50	VGNC	VGNC:66894
Mus musculus	USP50	MGD	MGI:1922333
Macaca mulatta	USP50	VGNC	VGNC:79232
Others	USP50	NCBI

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