USP50 - ubiquitin specific peptidase 50 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 373509

About USP50

This gene has 11 transcripts (splice variants), 172 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 3.5), bone marrow (RPKM 2.9) and 25 other tissues.

Summary

Enables ubiquitin-like protein-specific protease activity. Acts upstream of or within several processes, including nuclear speck organization; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of macromolecule metabolic process. Predicted to be active in several cellular components, including dendritic spine; midbody; and postsynaptic density. Predicted to be extrinsic component of endosome membrane and extrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

USP50 Products (1)

mRNA Protein Name
NM_203494.5 NP_987090.2 inactive ubiquitin carboxyl-terminal hydrolase 50

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
28094437 GOA
enables ubiquitin-like protein peptidase activity IDA
IDA: Inferred from direct assay
28094437 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within nuclear speck organization IMP
IMP: Inferred from mutant phenotype
28094437 GOA
acts upstream of or within positive regulation of NLRP3 inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
28094437 GOA
acts upstream of or within positive regulation of cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
28094437 GOA
acts upstream of or within positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
28094437 GOA
acts upstream of or within protein deubiquitination IDA
IDA: Inferred from direct assay
28094437 GOA
involved in regulation of cell cycle G2/M phase transition IMP
IMP: Inferred from mutant phenotype
20930503 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
20930503 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
20930503 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20930503 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP50 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (43 - 330)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

inactive ubiquitin carboxyl-terminal hydrolase 50

  • inactive ubiquitin-specific peptidase 50

Related Diseases

Diseases Alias
Spondyloarthropathy 1

  • Ankylosing Spondylitis

  • Spondyloarthropathy, Susceptibility To, 1

  • SPDA1

  • Marie-Strumpell Spondylitis

  • Bechterew Syndrome

  • Spa

  • Spondylarthritis Ankylopoietica

  • Reiter Syndrome

  • Ankylosing Spondylitis, Susceptibility To

  • Bekhterev Syndrome

  • Bekhterev'S Disease

  • Marie-Strumpell Disease

  • Axial Spondylarthritis

  • Bechterew Disease

  • Marie-Struempell Disease

  • Spondylitis Ankylopoietica

  • Spondyloarthritis

  • Spondyloarthritis Ankylopoietica

  • Spas

  • Ankylosing Spondylarthritis

  • Psoriatic Arthritis

  • Reactive Arthritis

  • Rheumatoid Spondylitis

  • Spondylitis Ankylosans

  • Spondylitis Ankylosing

  • Spondylitis, Ankylosing

  • Spondylarthropathies

  • Arthritis, Psoriatic

  • Arthritis, Reactive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15562 USP50 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22904 Usp50 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29418 Usp50 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris USP50 VGNC VGNC:55016
Rattus norvegicus USP50 RGD RGD:1564751
Bos taurus USP50 VGNC VGNC:52848
Felis catus USP50 VGNC VGNC:66894
Mus musculus USP50 MGD MGI:1922333
Macaca mulatta USP50 VGNC VGNC:79232
Others USP50 NCBI