Aim2 - absent in melanoma 2 Gene

Also Known as Gm1313; Ifi210

Species: Mus musculus

Gene Type: protein coding
Gene ID: 383619

Summary

Enables double-stranded DNA binding activity and identical protein binding activity. Involved in positive regulation of macromolecule metabolic process; pyroptosis; and regulation of defense response. Acts upstream of or within cellular response to interferon-beta. Located in cytoplasm. Part of AIM2 inflammasome complex. Orthologous to human AIM2 (absent in melanoma 2). [provided by Alliance of Genome Resources, Apr 2022]

Aim2 Products (1)

mRNA Protein Name
NM_001013779.2 NP_001013801.2 interferon-inducible protein AIM2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
19158679 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
19158676 MGI
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
23567559 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19158679 MGI
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
26197926 MGI
Biological Process GO Annotation Evidence References Source
involved in AIM2 inflammasome complex assembly IDA
IDA: Inferred from direct assay
23567559 MGI
involved in DNA damage response IDA
IDA: Inferred from direct assay
27846608 MGI
involved in T cell homeostasis IDA
IDA: Inferred from direct assay
33505023 MGI
involved in activation of innate immune response IDA
IDA: Inferred from direct assay
19158676 MGI
involved in brain development IDA
IDA: Inferred from direct assay
32350463 MGI
acts upstream of or within cellular response to interferon-beta IDA
IDA: Inferred from direct assay
19158679 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
26095253 MGI
involved in neuron cellular homeostasis IDA
IDA: Inferred from direct assay
32350463 MGI
involved in positive regulation of cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
19158676 MGI
involved in positive regulation of cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
19131592 MGI
involved in positive regulation of defense response to virus by host IMP
IMP: Inferred from mutant phenotype
19158675 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
19158676 MGI
acts upstream of or within positive regulation of interleukin-1 beta production IGI
IGI: Inferred from genetic interaction
23997220 MGI
involved in positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
19158675 MGI
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
19158676 MGI
involved in regulation of behavior IDA
IDA: Inferred from direct assay
32350463 MGI
Cellular Component GO Annotation Evidence References Source
part of AIM2 inflammasome complex IDA
IDA: Inferred from direct assay
19158679 MGI
is active in cytoplasm IDA
IDA: Inferred from direct assay
19158679 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19158679 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
27846608 MGI
is active in site of double-strand break IDA
IDA: Inferred from direct assay
27846608 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon-inducible protein AIM2

  • ifi-210

  • interferon-inducible protein 210

  • interferon-inducible protein p210

Aim2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Aim2 Q91VJ1 Aim2 Mus musculus Q91VJ1
Crosslink
19158676
Intra
Aim2 Q91VJ1 Ralb Mus musculus Q9JIW9
Confocal
22286270
Intra
Aim2 Q91VJ1 Exoc8 Mus musculus Q6PGF7
Confocal
22286270
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0822 Shikonin Inhibitor 99.80% Unkown
HY-12497 ANA-12 Inhibitor 99.90% Unkown
HY-144226 NLRP3/AIM2-IN-3 Inhibitor 98.23% Unkown
HY-150751 ODN TTAGGG Antagonist 99.87% Unkown
HY-150751C ODN TTAGGG sodium Antagonist 93.80% Unkown
HY-152670 JC2-11 Inhibitor 98.03% Unkown
HY-130480 Fructose-arginine Inhibitor 98.32% Unkown
HY-P11383 AIM2-derived decapeptide / Unkown
HY-12497R ANA-12 (Standard) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aim2 NCBI NCBI:9447