HACD4 - 3-hydroxyacyl-CoA dehydratase 4 Gene

Also Known as PTPLAD2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 401494

Summary

Enables enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Involved in fatty acid elongation and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Broad expression in lung (RPKM 8.9), bone marrow (RPKM 8.0) and 23 other tissues.

HACD4 Products (3)

mRNA Protein Name
NM_001010915.5 NP_001010915.2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform 1
NM_001321883.2 NP_001308812.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform 2
NM_001321903.2 NP_001308832.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IDA
IDA: Inferred from direct assay
18554506 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity IDA
IDA: Inferred from direct assay
18554506 GOA
Biological Process GO Annotation Evidence References Source
involved in fatty acid elongation IDA
IDA: Inferred from direct assay
18554506 GOA
involved in very long-chain fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
18554506 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18554506 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HACD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HACD4 Q5VWC8 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
HACD4 Q5VWC8 CD79A Homo sapiens P11912
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149897 HA-CD44 interaction inhibitor 2 Inhibitor 99.36% Unkown
HY-149898 HA-CD44 interaction inhibitor 1 Inhibitor 99.34% Unkown
HY-170955 HA-CD44 interaction inhibitor 3 Inhibitor / Unkown