MAS1 - MAS1 proto-oncogene, G protein-coupled receptor Gene

Also Known as MAS; MGRA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4142

About MAS1

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:159,888,787-159,917,447 (from NCBI)

This gene has 2 transcripts (splice variants), 118 orthologues and 10 paralogues.

Summary

This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the Phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]

MAS1 Products (2)

mRNA Protein Name
NM_001366704.2 NP_001353633.1 proto-oncogene Mas
NM_002377.4 NP_002368.1 proto-oncogene Mas

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
16611642 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26460884 GOA
Biological Process GO Annotation Evidence References Source
involved in phospholipase C-activating angiotensin-activated signaling pathway IMP
IMP: Inferred from mutant phenotype
16611642 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
16611642 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAS1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 280)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

proto-oncogene Mas

  • MAS1 oncogene

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08157 MAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08158 MAS1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10771 PMPCB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18949 Mas1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25439 Mas1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MAS1 VGNC VGNC:74661
Felis catus MAS1 VGNC VGNC:68187
Rattus norvegicus MAS1 RGD RGD:3049
Mus musculus MAS1 MGD MGI:96918
Bos taurus MAS1 VGNC VGNC:31254
Others MAS1 NCBI