TARM1 - T cell-interacting, activating receptor on myeloid cells 1 Gene

Also Known as OLT-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 441864

About TARM1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,069,895-54,081,365 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 238 orthologues and 25 paralogues. Restricted expression toward bone marrow (RPKM 2.5).

Summary

Enables immunoglobulin receptor binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TARM1 Products (2)

mRNA	Protein	Name
NM_001135686.3	NP_001129158.2	T-cell-interacting, activating receptor on myeloid cells protein 1 isoform 1 precursor
NM_001330650.1	NP_001317579.1	T-cell-interacting, activating receptor on myeloid cells protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables immunoglobulin receptor binding	IPI IPI: Inferred from physical interaction	26311901	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of CD4-positive, alpha-beta T cell activation	IDA IDA: Inferred from direct assay	26311901	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	26311901	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TARM1 Protein Structure

Ig_2

0
100
200
279 a.a.

Protein Preferred Names	Protein Names
T-cell-interacting, activating receptor on myeloid cells protein 1	OSCAR-like transcript-2 protein

Related Diseases

Diseases	Alias
Hypothyroidism, Central, With Testicular Enlargement	X-Linked Central Congenital Hypothyroidism With Late-Onset Testicular Enlargement CHTE Hypothyroidism, Central, And Testicular Enlargement Igsf1 Deficiency Syndrome X-Linked Central Congenital Hypothyroidism With Late-Onset Macroorchidism Central Hypothyroidism And Testicular Enlargement Hypothyroidism, Central, Testicular Enlargement
Facial Hemiatrophy	Parry-Romberg Syndrome
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14209	TARM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21061	Tarm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27578	Tarm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TARM1	VGNC	VGNC:35604
Rattus norvegicus	TARM1	RGD	RGD:1564272
Mus musculus	TARM1	MGD	MGI:2442280