ATF1 - activating transcription factor 1 Gene

Homo sapiens

Also known as TREB36; EWS-ATF1; FUS/ATF-1

Gene ID: 466 | Gene type: protein coding

About ATF1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,763,459-50,821,162 (from NCBI)

This gene has 5 transcripts (splice variants), 148 orthologues, 9 paralogues and is associated with 66 phenotypes. Ubiquitous expression in thyroid (RPKM 6.8), adrenal (RPKM 5.9) and 25 other tissues.

Summary

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

ATF1 Products(25)

mRNA	Protein	Name
NM_001412960.1	NP_001399889.1	cyclic AMP-dependent transcription factor ATF-1 isoform a
NM_001412961.1	NP_001399890.1	cyclic AMP-dependent transcription factor ATF-1 isoform b
NM_001412962.1	NP_001399891.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412963.1	NP_001399892.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412964.1	NP_001399893.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412965.1	NP_001399894.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412966.1	NP_001399895.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412967.1	NP_001399896.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412968.1	NP_001399897.1	cyclic AMP-dependent transcription factor ATF-1 isoform d
NM_001412969.1	NP_001399898.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412970.1	NP_001399899.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412971.1	NP_001399900.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412972.1	NP_001399901.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412973.1	NP_001399902.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412974.1	NP_001399903.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412975.1	NP_001399904.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412976.1	NP_001399905.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412977.1	NP_001399906.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412978.1	NP_001399907.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412979.1	NP_001399908.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412980.1	NP_001399909.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412981.1	NP_001399910.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412982.1	NP_001399911.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412983.1	NP_001399912.1	cyclic AMP-dependent transcription factor ATF-1 isoform g
NM_005171.5	NP_005162.1	cyclic AMP-dependent transcription factor ATF-1 isoform c

ATF1 Protein Structure

pKID

bZIP_1

0
100
200
271 a.a.

Protein Preferred Names

Protein Names

cyclic AMP-dependent transcription factor ATF-1

cAMP-dependent transcription factor ATF-1

Recombinant ATF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7615	ATF1 Protein, Human (His)	P18846 (M1-V271)	≥95%

Related Diseases

Diseases

Alias

Melanoma Of Soft Tissue

Clear Cell Sarcoma Of The Tendons And Aponeuroses

Fibrous Histiocytoma

Benign Fibrous Histiocytoma	Histiocytoma, Benign Fibrous
Fibroxanthoma	Histiocytoma Fibrous

Clear Cell Sarcoma

Sarcoma, Clear Cell	Adult Soft Part Clear Cell Sarcoma
Clear Cell Sarcoma Of Soft Parts	Malignant Melanoma Of Soft Parts
Malignant Melanoma Of Soft Tissues	Melanoma, Malignant, Of Soft Parts
Sarcoma Clear Cell

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Myxoid Chondrosarcoma

Sarcomatosis

Alveolar Soft Part Sarcoma

ASPS	Alveolar Soft-Part Sarcoma
Sarcoma, Alveolar Soft Part	Alveolar Soft Tissue Sarcoma
Sarcoma Alveolar Soft Part	Adult Alveolar Soft-Part Sarcoma
Childhood Alveolar Soft-Part Sarcoma

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma	Rhabdomyosarcoma, Alveolar
Rhabdomyosarcoma Alveolar	RMS2
Rmsa	Rhabdomyosarcoma 2, Alveolar
Alveolar Childhood Rhabdomyosarcoma	Arms
Rhabdomyosarcoma, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108618	BC11-38	Inhibitor	98.13%	Unkown
HY-RS01127	ATF1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATF1	VGNC	VGNC:38207
Rattus norvegicus	ATF1	RGD	RGD:1307360
Felis catus	ATF1	VGNC	VGNC:83504
Macaca mulatta	ATF1	VGNC	VGNC:108325
Mus musculus	ATF1	MGD	MGI:1298366
Bos taurus	ATF1	VGNC	VGNC:26239
Others	ATF1	NCBI

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