ATF1 - activating transcription factor 1 Gene

Also Known as TREB36; EWS-ATF1; FUS/ATF-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 466

About ATF1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,763,459-50,821,162 (from NCBI)

This gene has 5 transcripts (splice variants), 148 orthologues, 9 paralogues and is associated with 66 phenotypes. Ubiquitous expression in thyroid (RPKM 6.8), adrenal (RPKM 5.9) and 25 other tissues.

Summary

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and Other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

ATF1 Products (25)

mRNA	Protein	Name
NM_001412960.1	NP_001399889.1	cyclic AMP-dependent transcription factor ATF-1 isoform a
NM_001412961.1	NP_001399890.1	cyclic AMP-dependent transcription factor ATF-1 isoform b
NM_001412962.1	NP_001399891.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412963.1	NP_001399892.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412964.1	NP_001399893.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412965.1	NP_001399894.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412966.1	NP_001399895.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412967.1	NP_001399896.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412968.1	NP_001399897.1	cyclic AMP-dependent transcription factor ATF-1 isoform d
NM_001412969.1	NP_001399898.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412970.1	NP_001399899.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412971.1	NP_001399900.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412972.1	NP_001399901.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412973.1	NP_001399902.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412974.1	NP_001399903.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412975.1	NP_001399904.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412976.1	NP_001399905.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412977.1	NP_001399906.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412978.1	NP_001399907.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412979.1	NP_001399908.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412980.1	NP_001399909.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412981.1	NP_001399910.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412982.1	NP_001399911.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412983.1	NP_001399912.1	cyclic AMP-dependent transcription factor ATF-1 isoform g
NM_005171.5	NP_005162.1	cyclic AMP-dependent transcription factor ATF-1 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	1655749	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1655749	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20102225	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10722738	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	25644539	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1655749	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1655749	GOA
involved in response to purine-containing compound	IDA IDA: Inferred from direct assay	25644539	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ATF1-ATF4 transcription factor complex	IDA IDA: Inferred from direct assay	12871976	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8798441	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATF1 Protein Structure

pKID

bZIP_1

0
100
200
271 a.a.

Protein Preferred Names	Protein Names
cyclic AMP-dependent transcription factor ATF-1	cAMP-dependent transcription factor ATF-1

ATF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATF1	P18846	NFIL3	Homo sapiens	Q16649	Peptide Array	20102225
Intra	ATF1	P18846	NFATC1	Homo sapiens	O95644	TAP	25609649
Intra	ATF1	P18846	NFATC1	Homo sapiens	O95644	Pull Down	25609649
Intra	ATF1	P18846	CREB1	Homo sapiens	P16220	Peptide Array	20102225
Intra	ATF1	P18846	CREB1	Homo sapiens	P16220	TAP	25609649
Intra	ATF1	P18846	ESR1	Homo sapiens	P03372	Phage Display	21217774
Intra	ATF1	P18846	ATF1	Homo sapiens	P18846	Peptide Array	20102225
Intra	ATF1	P18846	ATF1	Homo sapiens	P18846	Solution Sedimentation	21045134
Cross	ATF1	P18846	HBZ	Human T-cell leukemia virus 1	P0C746	Peptide Array	20102225
Cross	ATF1	P18846	p03259-2	Human adenovirus A	P03259-2	Pull Down	10722738
Cross	ATF1	P18846	p03259-2	Human adenovirus A	P03259-2	Anti Bait CoIP	10722738

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7615	ATF1 Protein, Human (His)	P18846 (M1-V271)	≥ 95%, as determined by reducing SDS-PAGE.

ATF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83391	ATF1 Antibody (YA3136)	WB, IP	Human
HY-P83391A	ATF1 Antibody (YA3136)(PBS only)	WB, IP	Human

Related Diseases

Diseases	Alias
Melanoma Of Soft Tissue	Clear Cell Sarcoma Of The Tendons And Aponeuroses
Fibrous Histiocytoma	Benign Fibrous Histiocytoma Histiocytoma, Benign Fibrous Fibroxanthoma Histiocytoma Fibrous
Clear Cell Sarcoma	Sarcoma, Clear Cell Adult Soft Part Clear Cell Sarcoma Clear Cell Sarcoma Of Soft Parts Malignant Melanoma Of Soft Parts Malignant Melanoma Of Soft Tissues Melanoma, Malignant, Of Soft Parts Sarcoma Clear Cell
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Myxoid Chondrosarcoma
Sarcomatosis
Alveolar Soft Part Sarcoma	ASPS Alveolar Soft-Part Sarcoma Sarcoma, Alveolar Soft Part Alveolar Soft Tissue Sarcoma Sarcoma Alveolar Soft Part Adult Alveolar Soft-Part Sarcoma Childhood Alveolar Soft-Part Sarcoma
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103100	SB-699551		99.53%	Unkown
HY-108618	BC11-38	Inhibitor	99.42%	Unkown
HY-N12887	Mycothiazole	Inhibitor	/	Unkown
HY-RS01127	ATF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05361	GDNF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-136700	SB-699551 free base		/	Unkown
HY-RS18337	Atf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24816	Atf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATF1	VGNC	VGNC:38207
Rattus norvegicus	ATF1	RGD	RGD:1307360
Felis catus	ATF1	VGNC	VGNC:83504
Macaca mulatta	ATF1	VGNC	VGNC:108325
Mus musculus	ATF1	MGD	MGI:1298366
Bos taurus	ATF1	VGNC	VGNC:26239
Others	ATF1	NCBI