NCAM2 - neural cell adhesion molecule 2 Gene

Also Known as NCAM21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4685

About NCAM2

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:20,998,409-21,543,329 (from NCBI)

This gene has 5 transcripts (splice variants), 217 orthologues and 36 paralogues. Biased expression in brain (RPKM 13.1), adrenal (RPKM 3.2) and 3 other tissues.

Summary

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]

NCAM2 Products (8)

mRNA Protein Name
NM_001352591.2 NP_001339520.1 neural cell adhesion molecule 2 isoform 1 precursor
NM_001352592.2 NP_001339521.1 neural cell adhesion molecule 2 isoform 3
NM_001352593.2 NP_001339522.1 neural cell adhesion molecule 2 isoform 4 precursor
NM_001352594.2 NP_001339523.1 neural cell adhesion molecule 2 isoform 5 precursor
NM_001352595.2 NP_001339524.1 neural cell adhesion molecule 2 isoform 6 precursor
NM_001352596.2 NP_001339525.1 neural cell adhesion molecule 2 isoform 7 precursor
NM_001352597.2 NP_001339526.1 neural cell adhesion molecule 2 isoform 8
NM_004540.5 NP_004531.2 neural cell adhesion molecule 2 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
21300289 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCAM2 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (22 - 111)

I-set

I-set: Immunoglobulin I-set domain (117 - 191)

I-set

I-set: Immunoglobulin I-set domain (213 - 298)

I-set

I-set: Immunoglobulin I-set domain (306 - 396)

I-set

I-set: Immunoglobulin I-set domain (414 - 488)

fn3

fn3: Fibronectin type III domain (497 - 581)

fn3

fn3: Fibronectin type III domain (595 - 677)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 837 a.a.
Protein Preferred Names Protein Names

neural cell adhesion molecule 2

  • N-CAM-2

NCAM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NCAM2 O15394 HNRNPC Homo sapiens P07910
Crosslink
30021884
Intra
NCAM2 O15394 NCAM2 Homo sapiens O15394
GMS
21300289
Intra
NCAM2 O15394 SCG3 Homo sapiens Q8WXD2
Y2H Fragment Pooling
35914814
Intra
NCAM2 O15394 SCHIP1 Homo sapiens P0DPB3
Display Tech
20195357
Intra
NCAM2 O15394 CTNND2 Homo sapiens Q9UQB3
Y2H Fragment Pooling
35914814
Intra
NCAM2 O15394 YWHAH Homo sapiens Q04917
Y2H Fragment Pooling
35914814
Intra
NCAM2 O15394 CHD4 Homo sapiens Q14839
Y2H Fragment Pooling
35914814
Intra
NCAM2 O15394 YWHAB Homo sapiens P31946
Y2H Fragment Pooling
35914814
Intra
NCAM2 O15394 NCAM2 Homo sapiens O15394
X-Ray Diffraction
21300289
Intra
NCAM2 O15394 YWHAZ Homo sapiens P63104-1
Y2H Fragment Pooling
35914814
Intra
NCAM2 O15394 YWHAE Homo sapiens P62258
Y2H Fragment Pooling
35914814
Intra
NCAM2 O15394 RALY Homo sapiens Q9UKM9
Crosslink
30021884
Intra
NCAM2 O15394 NCAM2 Homo sapiens O15394
SAXS
21300289
Intra
NCAM2 O15394 YWHAG Homo sapiens P61981
Y2H Fragment Pooling
35914814
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCAM2 Proteins

Cat. No. Product Name Accession Purity
HY-P76505 OCAM/NCAM2 Protein, Human (HEK293, Fc) O15394-1/NP_004531.2 (L20-N697) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76506 OCAM/NCAM2 Protein, Human (HEK293, His) O15394-1/NP_004531.2 (L20-N697) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Lissencephaly 3

  • LIS3

  • Lissencephaly Due To Tuba1a Mutation

  • Lissencephaly Type 3

  • Lissencephaly, Type 3
Epilepsy, Familial Temporal Lobe, 7

  • Familial Temporal Lobe Epilepsy 7

  • ETL7

  • Epilepsy, Temporal Lobe, Familial, Type 7
Spinocerebellar Ataxia 37

  • Spinocerebellar Ataxia Type 37

  • SCA37

  • Spinocerebellar Ataxia With Altered Vertical Eye Movements
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09064 NCAM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10451 PHOX2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20997 Ncam2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27514 Ncam2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NCAM2 VGNC VGNC:43637
Bos taurus NCAM2 VGNC VGNC:31899
Felis catus NCAM2 VGNC VGNC:68422
Rattus norvegicus NCAM2 RGD RGD:1303131
Macaca mulatta NCAM2 VGNC VGNC:75137
Mus musculus NCAM2 MGD MGI:97282
Others NCAM2 NCBI