ROCK1 - Rho associated coiled-coil containing protein kinase 1 Gene

Canis lupus familiaris (sub-species: familiaris)

Gene ID: 480181 | Gene type: protein coding

About ROCK1

Primary_assembly 7: 66,927,171-67,066,030 forward strand.ROS_Cfam_1.0:CM025106.1

This gene has 3 transcripts (splice variants), 212 orthologues and 6 paralogues.

ROCK1 Products(3)

mRNA	Protein	Name
XM_038672501.1	XP_038528429.1	rho-associated protein kinase 1 isoform X3
XM_038672500.1	XP_038528428.1	rho-associated protein kinase 1 isoform X2
XM_038672499.1	XP_038528427.1	rho-associated protein kinase 1 isoform X1

ROCK1 Protein Structure

STKc_ROCK1

SMC_prok_B

HR1_ROCK1

ROCK_SBD

PH_ROCK

C1_ROCK1

0
300
600
900
1200
1355 a.a.

Protein Preferred Names

Protein Names

rho-associated protein kinase 1

Related Agents

Approval

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10583	Y-27632 dihydrochloride	Inhibitor	99.98%	Unkown
HY-10341	Fasudil Hydrochloride	Inhibitor	99.97%	Yes
HY-15307	Belumosudil	Inhibitor	99.83%	Yes
HY-15685	Ripasudil	Inhibitor	99.95%	Unkown
HY-10341A	Fasudil	Inhibitor	99.98%	Yes
HY-15307A	Belumosudil mesylate	Inhibitor	99.89%	Yes
HY-13911A	Hydroxyfasudil hydrochloride	Inhibitor	98.88%	Unkown
HY-13911	Hydroxyfasudil	Inhibitor	98.78%	Unkown
HY-10341C	Fasudil dihydrochloride	Inhibitor	99.98%	Yes
HY-10341B	Fasudil hydrochloride semihydrate	Inhibitor	/	Unkown
HY-15685A	Ripasudil free base	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109191	Sovesudil	Inhibitor	99.91%	Phase 3
HY-109191A	Sovesudil hydrochloride	Inhibitor	99.45%	Phase 3
HY-15687A	SAR407899	Inhibitor	99.67%	Phase 2
HY-16758	Verosudil	Inhibitor	98.22%	Phase 2
HY-15687	SAR407899 hydrochloride	Inhibitor	99.14%	Phase 2
HY-16758A	Verosudil hydrochloride	Inhibitor	/	Phase 2
HY-16071	AT13148	Inhibitor	99.20%	Phase 1

Pre-clinical Phase

Bioactive Molecules (38)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10071	Y-27632	Inhibitor	99.91%	Unkown
HY-15392	Chroman 1	Inhibitor	98.97%	Unkown
HY-15556	GSK269962A	Inhibitor	99.75%	Unkown
HY-11000	GSK429286A	Inhibitor	98.27%	Unkown
HY-119937	ROCK inhibitor-2	Inhibitor	99.92%	Unkown
HY-15755	RKI-1447	Inhibitor	98.02%	Unkown
HY-13300	SR-3677	Inhibitor	99.83%	Unkown
HY-10319	BAY-549	Inhibitor	99.46%	Unkown
HY-108518	SB-772077B dihydrochloride	Inhibitor	99.33%	Unkown
HY-18990	GSK180736A	Inhibitor	98.81%	Unkown
HY-12437	BDP5290	Inhibitor	98.90%	Unkown
HY-15392A	Chroman 1 dihydrochloride	Inhibitor	98.13%	Unkown
HY-15556A	GSK269962A hydrochloride	Inhibitor	99.73%	Unkown
HY-132302	Hu7691	Inhibitor	99.91%	Unkown
HY-149266	THK01	Inhibitor	99.80%	Unkown
HY-162596	NRL-1049	Inhibitor	99.96%	Unkown
HY-14362	GSK-25	Inhibitor	99.68%	Unkown
HY-110339	RKI-1447 dihydrochloride	Inhibitor	99.94%	Unkown
HY-100270	Rho-Kinase-IN-1	Inhibitor	99.91%	Unkown
HY-14227	LIMK-IN-1	Inhibitor	99.33%	Unkown
HY-122011	PF-4950834	Inhibitor	99.60%	Unkown
HY-125221	DJ4	Inhibitor	99.25%	Unkown
HY-126275	HSD1590	Inhibitor	99.00%	Unkown
HY-178821	ROCK2-IN-12	Inhibitor	98.02%	Unkown
HY-N12378	β-Patchoulene	Inhibitor	96.88%	Unkown
HY-107209	RKI-1313	Inhibitor	98.2%	Unkown
HY-132302A	Hu7691 free base	Inhibitor	/	Unkown
HY-172177	ROCK/HDAC-IN-2	Inhibitor	/	Unkown
HY-175843	ROCK2-IN-10	Inhibitor	/	Unkown
HY-164809	Desisopropyle-belumosudil	Inhibitor	/	Unkown
HY-181583	LASSBio-2389	Inhibitor	/	Unkown
HY-N15301	Nocarnickelamide B	Inhibitor	/	Unkown
HY-178013	ROCK2-IN-11	Inhibitor	/	Unkown
HY-13300A	SR-3677 dihydrochloride	Inhibitor	/	Unkown
HY-181582	LASSBio-2382	Inhibitor	/	Unkown
HY-W047432	5-Nitro-1H-indazole-3-carbonitrile	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-123939	JAK1/3-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ROCK1	NCBI	NCBI:6093

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