ERBB4 - erb-b2 receptor tyrosine kinase 4 Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 488508

About ERBB4

Primary_assembly 37: 18,980,387-20,127,189 reverse strand.ROS_Cfam_1.0:CM025136.1

This gene has 5 transcripts (splice variants), 227 orthologues and 54 paralogues.

ERBB4 Products (5)

mRNA Protein Name
XM_038447859.1 XP_038303787.1 receptor tyrosine-protein kinase erbB-4 isoform X5
XM_038447858.1 XP_038303786.1 receptor tyrosine-protein kinase erbB-4 isoform X4
XM_038447855.1 XP_038303783.1 receptor tyrosine-protein kinase erbB-4 isoform X1
XM_038447857.1 XP_038303785.1 receptor tyrosine-protein kinase erbB-4 isoform X3
XM_038447856.1 XP_038303784.1 receptor tyrosine-protein kinase erbB-4 isoform X2

ERBB4 Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (54 - 166)

Furin-like

Furin-like: pfam00757 (185 - 331)

Recep_L_domain

Recep_L_domain: pfam01030 (357 - 477)

GF_recep_IV

GF_recep_IV: pfam14843 (501 - 633)

TM_ErbB4

TM_ErbB4: cd12092 (641 - 684)

PTKc_HER4

PTKc_HER4: cd05110 (709 - 1011)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1308 a.a.
Protein Preferred Names Protein Names

receptor tyrosine-protein kinase erbB-4

  • v-erb-a erythroblastic leukemia viral oncogene homolog 4

  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13272 Dacomitinib 99.74% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13427 Allitinib tosylate Inhibitor 99.54% Phase 2

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B0793 AZ-5104 Inhibitor 99.91% Unkown
HY-N0353 Curdione Inhibitor 99.80% Unkown
HY-168438 ERBB agonist-1 99.16% Unkown
HY-18609 PD158780 Inhibitor 99.47% Unkown
HY-15375 Allitinib Inhibitor 98.88% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-103440 EGFR/ErbB-2/ErbB-4 inhibitor-3 Inhibitor 96.78% Unkown
HY-112420 EGFR/ErbB-2-IN-2 Inhibitor 99.45% Unkown
HY-103441 JNJ28871063 hydrochloride Inhibitor 98.36% Unkown
HY-RS04472 ERBB4 Human Pre-designed siRNA Set A / Unkown
HY-13272S2 Dacomitinib-d10 dihydrochloride ≥95.0% Unkown
HY-E70715 ERBB2 775YVMA776 Recombinant Human Active Protein Kinase / Unkown
HY-B0793S1 AZ-5104-d2 Inhibitor / Unkown
HY-13272S3 Dacomitinib-d10 / Unkown
HY-175809 SRT6 Inhibitor / Unkown
HY-RS04473 Erbb4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04474 Erbb4 Rat Pre-designed siRNA Set A / Unkown
HY-174565 Human NRG3 mRNA / Unkown
HY-174671 Human HBEGF mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ERBB4 NCBI NCBI:2066