NTF4 - neurotrophin 4 Gene

Also Known as NT4; NT5; NT-4; NT-5; NTF5; GLC10; GLC1O; NT-4/5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4909

About NTF4

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,058,284-49,065,035 (from NCBI)

This gene has 7 transcripts (splice variants), 177 orthologues, 3 paralogues and is associated with 2 phenotypes. Biased expression in skin (RPKM 4.5), prostate (RPKM 2.1) and 6 other tissues.

Summary

This gene is a member of a family of Neurotrophic Factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of Other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]

NTF4 Products (2)

mRNA	Protein	Name
NM_001395489.1	NP_001382418.1	neurotrophin-4 preproprotein
NM_006179.5	NP_006170.1	neurotrophin-4 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10631974	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTF4 Protein Structure

NGF

0
100
200
210 a.a.

Protein Preferred Names	Protein Names
neurotrophin-4	neurotrophic factor 4

NTF4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NTF4	P34130	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	25416956
Intra	NTF4	P34130	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	25416956
Intra	NTF4	P34130	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	NTF4	P34130	BDNF	Homo sapiens	P23560	PLA	25241761
Intra	NTF4	P34130	TRIM68	Homo sapiens	Q6AZZ1	Anti Tag CoIP	33961781
Intra	NTF4	P34130	TRIM68	Homo sapiens	Q6AZZ1	Anti Tag CoIP	28514442
Intra	NTF4	P34130	GLRX3	Homo sapiens	O76003	Y2H Array	32296183
Intra	NTF4	P34130	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	32296183
Intra	NTF4	P34130	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	NTF4	P34130	CRX	Homo sapiens	O43186	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NTF4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7272	Neurotrophin-4 Protein, Human	P34130 (G81-A210)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Glaucoma 1, Open Angle, O	GLC1O Glaucoma 1, Open Angle, 1o Primary Open Angle Glaucoma 1o
Open-Angle Glaucoma	Glaucoma Simplex Pigmentary Glaucoma Wide-Angle Glaucoma Glaucoma, Open-Angle Open Angle Glaucoma Glaucoma Open-Angle Chronic Simple Glaucoma Coag - [Chronic Open-Angle Glaucoma] Csg - [Chronic Simple Glaucoma] Poag - [Primary Open-Angle Glaucoma] Oag - [Open-Angle Glaucoma] Chronic Glaucoma Chronic Open Angle Glaucoma Simple Glaucoma Chronic Noncongestive Glaucoma Ltg - [Low Tension Glaucoma] Noncongestive Glaucoma Nonobstructive Glaucoma Normal Pressure Glaucoma Primary Low Tension Glaucoma Low-Tension Glaucoma Residual Stage Low Tension Glaucoma Open Cleft Glaucoma
Hypochondriasis	Hypochondriacal Disorder Hypochondria Hypochondriacal Neurosis Illness Anxiety Disorder Health Anxiety Disorder Hypochondriacal Reaction
Trichothiodystrophy 7, Nonphotosensitive	TTD7 Nonphotosensitive Trichothiodystrophy 7 Trichothiodystrophy 7, Non-Photosensitive
Asperger Syndrome	Asperger Disorder Asperger Syndrome, Susceptibility To
Glaucoma, Normal Tension	Low Tension Glaucoma Glaucoma, Normal Tension, Susceptibility To Normal Tension Glaucoma Ntg Glaucoma, Normal Pressure NPG Glaucoma, Normal Pressure, Susceptibility To Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]
Glaucoma, Primary Open Angle	Glaucoma 1, Open Angle, E Primary Open Angle Glaucoma POAG Adult-Onset Primary Open Angle Glaucoma Chronic Simple Glaucoma GLC1E Primary Open Angle Glaucoma 1e Glaucoma, Open Angle, Primary
Primary Congenital Glaucoma
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Juvenile Glaucoma	Glaucoma Of Childhood Hydrophthalmos
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09617	NTF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25451	Ntf4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NTF4	RGD	RGD:3212
Mus musculus	NTF4	MGD	MGI:97381
Bos taurus	NTF4	VGNC	VGNC:32300
Canis familiaris	NTF4	VGNC	VGNC:44003
Felis catus	NTF4	VGNC	VGNC:97539
Others	NTF4	NCBI