Sting1 - stimulator of interferon response cGAMP interactor 1 Gene

Also Known as rSTING; Tmem173; RGD1562552

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 498840

About Sting1

Biased expression in Spleen (RPKM 75.4), Thymus (RPKM 42.2) and 9 other tissues.

Summary

Enables 2',3'-cyclic GMP-AMP binding activity. Involved in cellular response to organic cyclic compound and positive regulation of type I interferon production. Predicted to be located in several cellular components, including mitochondrial outer membrane; perinuclear region of cytoplasm; and peroxisome. Predicted to be integral component of endoplasmic reticulum membrane and integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane. Predicted to be active in autophagosome and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sting1 Products (1)

mRNA Protein Name
NM_001109122.1 NP_001102592.1 stimulator of interferon genes protein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 2',3'-cyclic GMP-AMP binding IDA
IDA: Inferred from direct assay
26669264 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
26669264 RGD
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
26669264 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sting1 Protein Structure

TMEM173

TMEM173: pfam15009 (43 - 336)

  • 0
  • 100
  • 200
  • 300
  • 379 a.a.
Protein Preferred Names Protein Names

stimulator of interferon genes protein

  • mitochondrial transmembrane protein 173

  • transmembrane protein 173

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112906 C-176 Inhibitor 99.22% Unkown
HY-114399 STING ligand-1 99.65% Unkown
HY-138683 STING-IN-3 Inhibitor 99.75% Unkown
HY-12885C 2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt Inducer 98.94% Unkown
HY-RS13916 STING1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13917 Sting1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13918 Sting1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-163643 STING modulator-7 Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sting1 NCBI NCBI:340061