STING1 - stimulator of interferon response cGAMP interactor 1 Gene

Also Known as ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 340061

About STING1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,475,533-139,482,758 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 184 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lung (RPKM 37.4), spleen (RPKM 28.8) and 24 other tissues.

Summary

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and Bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

STING1 Products (3)

mRNA	Protein	Name
NM_001301738.2	NP_001288667.1	stimulator of interferon genes protein isoform 2
NM_001367258.1	NP_001354187.1	stimulator of interferon genes protein isoform 3 precursor
NM_198282.4	NP_938023.1	stimulator of interferon genes protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 2',3'-cyclic GMP-AMP binding	IDA IDA: Inferred from direct assay	23747010	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	18818105	GOA
enables cyclic-di-GMP binding	IDA IDA: Inferred from direct assay	22705373	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19433799	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18724357	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	19433799	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	18818105	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21074459	GOA
enables proton channel activity	IDA IDA: Inferred from direct assay	37535724	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	23747010	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	23910378	GOA
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	18818105	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	21074459	GOA
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	30568238	GOA
involved in cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	25636800	GOA
involved in cellular response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	18818105	GOA
involved in cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	26669264	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	23910378	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21074459	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	21074459	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	19433799	GOA
involved in pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	23910378	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18818105	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	18818105	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	21074459	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	19433799	GOA
involved in positive regulation of macroautophagy	IDA IDA: Inferred from direct assay	30568238	GOA
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	18818105	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18818105	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	22394562	GOA
involved in positive regulation of type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	23910378	GOA
acts upstream of protein complex oligomerization	IDA IDA: Inferred from direct assay	35388221	GOA
involved in protein complex oligomerization	IDA IDA: Inferred from direct assay	30842659	GOA
involved in protein localization to endoplasmic reticulum	IDA IDA: Inferred from direct assay	37832545	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in Golgi membrane	IDA IDA: Inferred from direct assay	37535724	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	29973723	GOA
part of STING complex	IPI IPI: Inferred from physical interaction	30405246	GOA
located in autophagosome	IDA IDA: Inferred from direct assay	29694889	GOA
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	37832545	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	19433799	GOA
is active in endoplasmic reticulum-Golgi intermediate compartment membrane	IDA IDA: Inferred from direct assay	32690950	GOA
located in endoplasmic reticulum-Golgi intermediate compartment membrane	IDA IDA: Inferred from direct assay	30842662	GOA
located in endosome	IDA IDA: Inferred from direct assay	29694889	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	18818105	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STING1 Protein Structure

TMEM173

0
100
200
300
379 a.a.

Protein Preferred Names	Protein Names
stimulator of interferon genes protein	N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner endoplasmic reticulum IFN stimulator endoplasmic reticulum interferon stimulator mitochondrial mediator of IRF3 activation stimulator of interferon protein transmembrane protein 173

STING1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STING1	Q86WV6	LTN1	Homo sapiens	O94822	Anti Tag CoIP	21903422
Intra	STING1	Q86WV6	SURF4	Homo sapiens	O15260	Anti Tag CoIP	21903422
Intra	STING1	Q86WV6	SURF4	Homo sapiens	O15260	Anti Bait CoIP	29251827
Intra	STING1	Q86WV6	SGPL1	Homo sapiens	O95470	Anti Tag CoIP	21903422
Intra	STING1	Q86WV6	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	STING1	Q86WV6	STAT6	Homo sapiens	P42226	Y2H	22000020
Intra	STING1	Q86WV6	STAT6	Homo sapiens	P42226	Anti Tag CoIP	22000020
Intra	STING1	Q86WV6	STAT6	Homo sapiens	P42226	Confocal	22000020
Intra	STING1	Q86WV6	REEP6	Homo sapiens	Q96HR9-2	Validated Y2H	32296183
Intra	STING1	Q86WV6	MAVS	Homo sapiens	Q7Z434-1	Anti Tag CoIP	18724357
Intra	STING1	Q86WV6	MAVS	Homo sapiens	Q7Z434-1	Anti Bait CoIP	19416887
Intra	STING1	Q86WV6	RIGI	Homo sapiens	O95786-1	Anti Tag CoIP	18724357
Cross	STING1	Q86WV6	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	Anti Tag CoIP	24622840
Intra	STING1	Q86WV6	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	24622840
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	23542348
Intra	STING1	Q86WV6	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	18724357
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	19433799
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	X-Ray Diffraction	22728658
Intra	STING1	Q86WV6	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	21903422
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	X-Ray Diffraction	30405246
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	DLS	22728660
Intra	STING1	Q86WV6	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	19433799
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	GMS	22728658
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	X-Ray Diffraction	22728659
Intra	STING1	Q86WV6	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	23542348
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	Comig Non-Denat Gel	19433799
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	X-Ray Diffraction	22728660
Intra	STING1	Q86WV6	TBK1	Homo sapiens	Q9UHD2	Anti Bait CoIP	19416887
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	Comigration in SDS	19433799
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	3D-EM	30842659
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	GMS	22728660
Intra	STING1	Q86WV6	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	22312431
Intra	STING1	Q86WV6	SSR2	Homo sapiens	P43308	Anti Tag CoIP	18724357
Intra	STING1	Q86WV6	SSR2	Homo sapiens	P43308	Y2H	18724357
Intra	STING1	Q86WV6	IFI16	Homo sapiens	Q16666	Anti Tag CoIP	20890285
Intra	STING1	Q86WV6	IFI16	Homo sapiens	Q16666	Anti Bait CoIP	20890285
Intra	STING1	Q86WV6	TECR	Homo sapiens	Q9NZ01	Validated Y2H	32296183
Intra	STING1	Q86WV6	IFIT2	Homo sapiens	P09913	Anti Bait CoIP	19416887
Intra	STING1	Q86WV6	IFIT2	Homo sapiens	P09913	Anti Tag CoIP	19416887
Intra	STING1	Q86WV6	IRAK1	Homo sapiens	P51617	Anti Tag CoIP	21903422
Intra	STING1	Q86WV6	DDOST	Homo sapiens	P39656	Anti Tag CoIP	21903422
Intra	STING1	Q86WV6	PLLP	Homo sapiens	Q9Y342	Validated Y2H	32296183
Intra	STING1	Q86WV6	MBOAT7	Homo sapiens	Q96N66	Anti Tag CoIP	21903422
Intra	STING1	Q86WV6	STT3A	Homo sapiens	P46977	Anti Tag CoIP	21903422
Intra	STING1	Q86WV6	CCDC47	Homo sapiens	Q96A33	Anti Tag CoIP	21903422
Intra	STING1	Q86WV6	IFIT1	Homo sapiens	P09914	Anti Bait CoIP	19416887
Intra	STING1	Q86WV6	IFIT1	Homo sapiens	P09914	Anti Tag CoIP	19416887
Intra	STING1	Q86WV6	YIPF2	Homo sapiens	Q9BWQ6	Validated Y2H	32296183
Intra	STING1	Q86WV6	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183
Intra	STING1	Q86WV6	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	23542348
Intra	STING1	Q86WV6	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	22911572
Intra	STING1	Q86WV6	MAVS	Homo sapiens	Q7Z434	Confocal	22911572
Intra	STING1	Q86WV6	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	22312431
Intra	STING1	Q86WV6	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	24622840
Cross	STING1	Q86WV6	e1a_ade05	Human adenovirus C	P03255	Anti Tag CoIP	26405230
Cross	STING1	Q86WV6	Q99IB8-PRO_0000045601	Hepatitis C virus	Q99IB8-PRO_0000045601	Confocal	23542348
Cross	STING1	Q86WV6	P27958-PRO_0000037575	Hepatitis C virus	P27958-PRO_0000037575	Anti Tag CoIP	22911572

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STING1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70700	Sting1/TMEM173 Protein, Human (Sumo-His)	Q86WV6 (V155-V341)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70700A	Sting1/TMEM173 Protein, Human (N-His-Sumo)	Q86WV6 (V155-V341)	≥ 95%, as determined by reducing SDS-PAGE.

STING1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80350	STING Antibody (YA048)	WB, FC	Human
HY-P80940	STING Antibody	WB	Human, Mouse
HY-P810540	Phospho-STING (Ser366) Antibody (YA9809)	WB, Dot Blot, IP	Human
HY-P86617	STING Antibody (YA6309)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
Sting-Associated Vasculopathy, Infantile-Onset	SAVI Autoinflammatory-Vasculopathy Syndrome
Vascular Skin Disease	Skin Diseases, Vascular Skin Vascular Disease
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Smallpox	Variola Ordinary Smallpox Alastrim Amaas
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Crv Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Autoimmune Disease Of Cardiovascular System
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset
Severe Covid-19
Niemann-Pick Disease	Sphingomyelin/Cholesterol Lipidosis Niemann-Pick Diseases Lipoid Histiocytosis Sphingomyelin Lipidosis Sphingomyelinase Deficiency Disease Lipid Histiocytosis Neuronal Cholesterol Lipidosis Neuronal Lipidosis Npd Sphingomyelinase Deficiency Niemann-Pick Disease, Type A
Familial Cold Autoinflammatory Syndrome 3	Plaid Familial Atypical Cold Urticaria Facu FCAS3 Antibody Deficiency And Immune Dysregulation, Plcg2-Associated Plcg2-Associated Antibody Deficiency And Immune Dysregulation Familial Cold Urticaria With Common Variable Immunodeficiency Plcg2 Associated Antibody Deficiency And Immune Dysregulation Antibody Deficiency And Immune Dysregulation Placg2-Associated Autoinflammatory Syndrome, Cold, Familial, Type 3
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Trichohepatoenteric Syndrome 1	Trichohepatoenteric Syndrome Syndromic Diarrhea Tricho-Hepato-Enteric Syndrome Sd/The Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome THES1 Phenotypic Diarrhea Thes Phenotypic Diarrhea Of Infancy Diarrhea, Syndromic Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa Intractable Diarrhea With Phenotypic Anomalies Syndromatic Diarrhea Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Familial Chilblain Lupus
Interstitial Lung Disease	Ild Lung Diseases, Interstitial Lung Diseases Interstitial Interstitial Lung Diseases
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112906	C-176	Inhibitor	99.22%	Unkown
HY-114399	STING ligand-1		99.65%	Unkown
HY-138683	STING-IN-3	Inhibitor	99.75%	Unkown
HY-12885C	2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt	Inducer	98.94%	Unkown
HY-RS13916	STING1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13917	Sting1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13918	Sting1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-163643	STING modulator-7	Modulator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STING1	VGNC	VGNC:79674
Mus musculus	STING1	MGD	MGI:1919762
Canis familiaris	STING1	VGNC	VGNC:47498
Felis catus	STING1	VGNC	VGNC:66290
Rattus norvegicus	STING1	RGD	RGD:1562552
Bos taurus	STING1	VGNC	VGNC:35997
Others	STING1	NCBI