IFI16 - interferon gamma inducible protein 16 Gene

Also Known as PYHIN2; IFNGIP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3428

About IFI16

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:158,999,976-159,055,151 (from NCBI)

This gene has 13 transcripts (splice variants), 52 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 45.3), appendix (RPKM 41.3) and 24 other tissues.

Summary

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

IFI16 Products (8)

mRNA	Protein	Name
NM_001206567.2	NP_001193496.1	gamma-interferon-inducible protein 16 isoform 1
NM_001364867.2	NP_001351796.1	gamma-interferon-inducible protein 16 isoform 3
NM_001376587.1	NP_001363516.1	gamma-interferon-inducible protein 16 isoform 3
NM_001376588.1	NP_001363517.1	gamma-interferon-inducible protein 16 isoform 2
NM_001376589.1	NP_001363518.1	gamma-interferon-inducible protein 16 isoform 2
NM_001376591.1	NP_001363520.1	gamma-interferon-inducible protein 16 isoform 4
NM_001376592.1	NP_001363521.1	gamma-interferon-inducible protein 16 isoform 4
NM_005531.3	NP_005522.2	gamma-interferon-inducible protein 16 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	7536752	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9718316	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11146555	GOA
enables transcription factor binding	IDA IDA: Inferred from direct assay	12894224	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	21575908	GOA
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	21575908	GOA
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	21573174	GOA
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	14654789	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	21575908	GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	21573174	GOA
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA IDA: Inferred from direct assay	14654789	GOA
involved in monocyte differentiation	IDA IDA: Inferred from direct assay	9766636	GOA
involved in negative regulation of AIM2 inflammasome complex assembly	IDA IDA: Inferred from direct assay	30104205	GOA
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	22291595	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9642285	GOA
involved in negative regulation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	22046441	GOA
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	24413532	GOA
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	22046441	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12894224	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22046441	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	22291595	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	21575908	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11146555	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21575908	GOA
involved in regulation of autophagy	IEP IEP: Inferred from expression pattern	21573174	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	30104205	GOA
colocalizes with cytosol	IPI IPI: Inferred from physical interaction	24531343	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	19158679	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	14654789	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	14654789	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7536752	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFI16 Protein Structure

PYRIN

HIN

0
200
400
600
785 a.a.

Protein Preferred Names	Protein Names
gamma-interferon-inducible protein 16	interferon-gamma induced protein IFI 16

IFI16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IFI16	Q16666	BRCA1	Homo sapiens	P38398	Confocal	14654789
Intra	IFI16	Q16666	BRCA1	Homo sapiens	P38398	Anti Bait CoIP	14654789
Intra	IFI16	Q16666	BRCA1	Homo sapiens	P38398	Pull Down	14654789
Intra	IFI16	Q16666	AR	Homo sapiens	P10275	Anti Bait CoIP	16494870
Intra	IFI16	Q16666	AR	Homo sapiens	P10275	Pull Down	16494870
Intra	IFI16	Q16666	DHX58	Homo sapiens	Q96C10	Pull Down	30833792

Cross: Cross-species interaction Intra: Intraspecies interaction

IFI16 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810054	IFI-16 Antibody (YA9398)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
HY-P811251	IFI16 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset
Genital Herpes	Herpes Genitalis Genital Herpes Simplex Venereal Herpes Virus-Genital Herpes
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06552	IFI16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-160222	HSV-60mer sodium		98.11%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IFI16	VGNC	VGNC:73562
Others	IFI16	NCBI