1. Immunology/Inflammation
  2. STING
  3. STING ligand-1

STING ligand-1 

Cat. No.: HY-114399
Handling Instructions

STING ligand-1 is a lead STING ligand with an IC50 of 68 nM for HAQ STING.

For research use only. We do not sell to patients.

STING ligand-1 Chemical Structure

STING ligand-1 Chemical Structure

CAS No. : 2365039-41-2

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Description

STING ligand-1 is a lead STING ligand with an IC50 of 68 nM for HAQ STING[1].

IC50 & Target

IC50: 68 nM (HAQ STING)[1]

In Vitro

STING ligand-1 (Compound 18) exhibits functional inhibition of STING mediated cytokine release[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

523.98

Formula

C₂₉H₂₇ClFNO₅

CAS No.

2365039-41-2

SMILES

O=C1C2=CC(F)=CC=C2[[email protected]](CC(O)=O)[[email protected]@H](C3=CC(OCCO4)=C4C=C3)N1C5=CC(Cl)=C(C(C)(C)C)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (477.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9085 mL 9.5423 mL 19.0847 mL
5 mM 0.3817 mL 1.9085 mL 3.8169 mL
10 mM 0.1908 mL 0.9542 mL 1.9085 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (3.97 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

STING ligand-1STING ligand1STING ligand 1STINGStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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Product Name:
STING ligand-1
Cat. No.:
HY-114399
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