MBOAT7 - membrane bound O-acyltransferase domain containing 7 Gene

Homo sapiens

Also known as BB1; LRC4; LENG4; LPIAT; LPLAT; MBOA7; MRT57; OACT7; LPIAT1; LPLAT11; hMBOA-7

Gene ID: 79143 | Gene type: protein coding

About MBOAT7

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,173,415-54,189,580 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 185 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 19.3), adrenal (RPKM 15.7) and 25 other tissues.

Summary

This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have Acyltransferase activity. The encoded protein is a lysophosphatidylinositol Acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of Phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

MBOAT7 Products(4)

mRNA	Protein	Name
NM_001146056.3	NP_001139528.1	lysophospholipid acyltransferase 7 isoform 2
NM_001146082.3	NP_001139554.1	lysophospholipid acyltransferase 7 isoform 3
NM_001146083.3	NP_001139555.1	lysophospholipid acyltransferase 7 isoform 2
NM_024298.5	NP_077274.3	lysophospholipid acyltransferase 7 isoform 1

MBOAT7 Protein Structure

MBOAT

0
100
200
300
400
472 a.a.

Protein Preferred Names

Protein Names

lysophospholipid acyltransferase 7

1-acylglycerophosphatidylinositol O-acyltransferase

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 57

MRT57

Autosomal Recessive Intellectual Developmental Disorder 57

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Fatty Liver Disease

Alcoholic Fatty Liver	Fatty Liver
Fatty Liver, Alcoholic	Fatty Change Of Liver
Hepatic Lipidosis	Steatosis Of Liver
Fatty Liver Alcoholic	Steatohepatitis
Etoh Fatty Liver	Etoh Fatty Liver Metamorphosis
Fatty Etoh Liver Necrosis

Non-Alcoholic Steatohepatitis

Nonalcoholic Steatohepatitis	Nash
Nash - [Non-Alcoholic Steatohepatitis]	Non-Alcoholic Steatohepatosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08195	MBOAT7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MBOAT7	RGD	RGD:1306945
Mus musculus	MBOAT7	MGD	MGI:1924832
Felis catus	MBOAT7	VGNC	VGNC:63406
Canis familiaris	MBOAT7	VGNC	VGNC:43062
Bos taurus	MBOAT7	VGNC	VGNC:31289

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