Unc93b1 - unc-93 homolog B1, TLR signaling regulator Gene

Also Known as Unc93b; Unc-93B1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 54445

Summary

Enables Toll-like Receptor binding activity. Involved in intracellular protein transport and Toll-like Receptor signaling pathway. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of cytokine production; and Toll-like Receptor signaling pathway. Located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human UNC93B1 (unc-93 homolog B1, TLR signaling regulator). [provided by Alliance of Genome Resources, Apr 2022]

Unc93b1 Products (4)

mRNA	Protein	Name
NM_001161428.2	NP_001154900.2	protein unc-93 homolog B1 isoform b
NM_001403609.1	NP_001390538.1	protein unc-93 homolog B1 isoform c
NM_001403610.1	NP_001390539.1	protein unc-93 homolog B1 isoform d
NM_019449.3	NP_062322.3	protein unc-93 homolog B1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Toll-like receptor binding	IPI IPI: Inferred from physical interaction	17452530	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18931679	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	16415873	MGI
acts upstream of or within antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	20457904	MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP IMP: Inferred from mutant phenotype	16415873	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	20457904	MGI
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	18305481	MGI
acts upstream of or within positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	20457904	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	20457904	MGI
involved in toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	16415873	MGI
involved in toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	16415873	MGI
involved in toll-like receptor 9 signaling pathway	IDA IDA: Inferred from direct assay	38169466	MGI
involved in toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	16415873	MGI
acts upstream of or within toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16415873	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in early phagosome	IDA IDA: Inferred from direct assay	18305481	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16415873	MGI
located in endosome	IDA IDA: Inferred from direct assay	18305481	MGI
located in lysosome	IDA IDA: Inferred from direct assay	18305481	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein unc-93 homolog B1	unc-93 homolog B

Unc93b1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Unc93b1	Q8VCW4	SURF4	Homo sapiens	O15260	Anti Tag CoIP	21903422
Cross	Unc93b1	Q8VCW4	CLPTM1	Homo sapiens	O96005	Anti Tag CoIP	21903422
Cross	Unc93b1	Q8VCW4	IRAK1	Homo sapiens	P51617	Anti Tag CoIP	21903422
Cross	Unc93b1	Q8VCW4	MBOAT7	Homo sapiens	Q96N66	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15476	UNC93B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22053	Unc93b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28571	Unc93b1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Unc93b1	NCBI	NCBI:81622