Fxn - frataxin Gene

Also Known as RGD1565754

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 499335

Summary

Enables enzyme binding activity. Involved in positive regulation of axon extension; response to organic cyclic compound; and response to xenobiotic stimulus. Located in mitochondrion. Human ortholog(s) of this gene implicated in Friedreich ataxia; Friedreich ataxia 1; and type 2 diabetes mellitus. Orthologous to human FXN (frataxin). [provided by Alliance of Genome Resources, Apr 2022]

Fxn Products (1)

mRNA Protein Name
NM_001395132.1 NP_001382061.1 frataxin, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
15247478 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose starvation IEP
IEP: Inferred from expression pattern
21863062 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
26071548 RGD
involved in iron import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
26071548 RGD
involved in negative regulation of lipid storage IMP
IMP: Inferred from mutant phenotype
24751525 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
24242291 RGD
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
18809400 RGD
involved in positive regulation of mitochondrial membrane permeability IMP
IMP: Inferred from mutant phenotype
29223733 RGD
involved in regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
24242291 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18809400 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18809400 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
21863062 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

frataxin, mitochondrial

Recombinant Fxn Proteins

Cat. No. Product Name Accession Purity
HY-P72200 FXN Protein, Rat D3ZYW7 (L41-T208) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0364A Dyclonine hydrochloride 99.12% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-149737 FXn / Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05162 FXN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0364AS Dyclonine-d9 hydrochloride / Unkown
HY-158740 1(R)-(Trifluoromethyl)oleyl alcohol Inhibitor / Unkown
HY-RS18448 Fxn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24930 Fxn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fxn NCBI NCBI:2395