Sox2 - SRY-box transcription factor 2 Gene

Also Known as RGD1565646

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 499593

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including adenohypophysis development; positive regulation of transcription by RNA polymerase II; and tissue regeneration. Located in nucleus. Human ortholog(s) of this gene implicated in breast cancer; nasal cavity cancer; and syndromic microphthalmia 3. Orthologous to human SOX2 (SRY-box transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Sox2 Products (1)

mRNA Protein Name
NM_001109181.2 NP_001102651.1 transcription factor SOX-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12637543 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12637543 RGD
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
12637543 RGD
Biological Process GO Annotation Evidence References Source
involved in adenohypophysis development IEP
IEP: Inferred from expression pattern
21815952 RGD
involved in positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
19161985 RGD
involved in positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
20869108 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12637543 RGD
involved in regulation of myofibroblast cell apoptotic process IMP
IMP: Inferred from mutant phenotype
34321385 RGD
involved in response to oxygen-glucose deprivation IMP
IMP: Inferred from mutant phenotype
34321385 RGD
involved in tissue regeneration IEP
IEP: Inferred from expression pattern
19845688 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12637543 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor SOX-2

  • SRY (sex determining region Y)-box 2

  • SRY box 2

  • SRY-box containing gene 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12303 OAC1 Activator 99.85% Unkown
HY-B1238 Pronethalol Inhibitor 99.88% Unkown
HY-150082 CP681301 Inhibitor 99.18% Unkown
HY-18772 O4I2 99.18% Unkown
HY-RS13591 SOX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-18771 O4I1 Activator 98.05% Unkown
HY-173076A HDAC11-IN-1 TFA Inhibitor 99.25% Unkown
HY-15313B CBB1007 hydrochloride Inhibitor 98.0% Unkown
HY-N19791 6-Methoxymellein Inhibitor 97.69% Unkown
HY-RS16652 Sox2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-143443 DS17701585 Inhibitor / Unkown
HY-129108 9-cis-UAB30 / Unkown
HY-132974 Aminoflavone / Unkown
HY-165606 SB-T-1214 Inducer / Unkown
HY-168885 ZSH-512 / Unkown
HY-173076 HDAC11-IN-1 Inhibitor / Unkown
HY-175164 SVC112 / Unkown
HY-179339 LSD1-IN-46 Inhibitor / Unkown
HY-181781 LSD1-IN-48 / Unkown
HY-183202 NCD38 / Unkown
HY-183335 SMO-IN-6 / Unkown
HY-B1238A Pronethalol hydrochloride Inhibitor / Unkown
HY-119666 Rooperol Activator / Unkown
HY-174539 Human SOX2 mRNA / Unkown
HY-N15201 Betavulgarin Inhibitor / Unkown
HY-RS23087 Sox2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24311 Qsox1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sox2 NCBI NCBI:6657