Runx1 - RUNX family transcription factor 1 Gene

Also Known as Aml1; Cbfa2; PEA2-alpha; CBF-alpha-2; PEBP2-alpha

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50662

Summary

Enables promoter-specific chromatin binding activity and sequence-specific double-stranded DNA binding activity. Involved in several processes, including ovulation; positive regulation of progesterone secretion; and response to denervation involved in regulation of muscle adaptation. Located in chromatin and nucleus. Used to study middle cerebral artery infarction. Biomarker of endometriosis. Human ortholog(s) of this gene implicated in acute myeloid leukemia and esophagus squamous cell carcinoma. Orthologous to human RUNX1 (RUNX family transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Runx1 Products (1)

mRNA Protein Name
NM_017325.2 NP_059021.1 runt-related transcription factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
19342459 RGD
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
19342459 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19342459 RGD
involved in positive regulation of progesterone secretion IMP
IMP: Inferred from mutant phenotype
16675540 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21678417 RGD
involved in response to denervation involved in regulation of muscle adaptation IEP
IEP: Inferred from expression pattern
7969143 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
21678417 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

runt-related transcription factor 1

  • PEA2-alpha B

  • PEBP2-alpha B

  • acute myeloid leukemia 1 protein

  • core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene)

  • core-binding factor subunit alpha-2

  • oncogene AML-1

  • polyomavirus enhancer-binding protein 2 alpha B subuni

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108470 Ro5-3335 Inhibitor 99.52% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Runx1 NCBI NCBI:861