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Prkn - parkin RBR E3 ubiquitin protein ligase Gene

Also Known as Park2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 50873

Summary

Enables ubiquitin protein Ligase activity. Involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway; positive regulation of cellular protein metabolic process; and positive regulation of dendrite extension. Acts upstream of or within several processes, including Catecholamine metabolic process; chemical synaptic transmission; and Mitophagy. Located in mitochondrion; neuron projection; and nucleus. Part of protein-containing complex. Is expressed in several structures, including face; nervous system; pancreas; sensory organ; and skeleton. Used to study Parkinson's disease 2. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian Cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Prkn Products (3)

mRNA	Protein	Name
NM_001317726.2	NP_001304655.1	E3 ubiquitin-protein ligase parkin isoform 2
NM_001403470.1	NP_001390399.1	E3 ubiquitin-protein ligase parkin isoform 3
NM_016694.5	NP_057903.1	E3 ubiquitin-protein ligase parkin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12628165	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	20064468	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	18346797	MGI
involved in cellular response to toxic substance	IDA IDA: Inferred from direct assay	12628165	MGI
NOT acts upstream of or within dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	15684050	MGI
acts upstream of or within dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	12915482	MGI
acts upstream of or within dopamine uptake involved in synaptic transmission	IMP IMP: Inferred from mutant phenotype	12915482	MGI
NOT acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	15684050	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	12915482	MGI
NOT acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	15684050	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	12915482	MGI
acts upstream of or within mitophagy	IGI IGI: Inferred from genetic interaction	24949970	MGI
acts upstream of or within modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12930822	MGI
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21113145	MGI
involved in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	17116640	MGI
involved in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	23453807	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12628165	MGI
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	23858059	MGI
acts upstream of or within norepinephrine metabolic process	IMP IMP: Inferred from mutant phenotype	15249681	MGI
involved in positive regulation of dendrite extension	IGI IGI: Inferred from genetic interaction	24898855	MGI
involved in positive regulation of protein linear polyubiquitination	IMP IMP: Inferred from mutant phenotype	23453807	MGI
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	21376232	MGI
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	19591802	MGI
involved in protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	23858059	MGI
acts upstream of or within protein metabolic process	IMP IMP: Inferred from mutant phenotype	14985362	MGI
involved in regulation of mitochondrial membrane potential	IGI IGI: Inferred from genetic interaction	24898855	MGI
acts upstream of or within regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	12930822	MGI
involved in regulation of synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	29311685	MGI
involved in regulation of synaptic vesicle endocytosis	IEP IEP: Inferred from expression pattern	29311685	MGI
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	29311685	MGI
involved in regulation protein catabolic process at presynapse	IDA IDA: Inferred from direct assay	29311685	MGI
involved in regulation protein catabolic process at presynapse	IEP IEP: Inferred from expression pattern	29311685	MGI
involved in regulation protein catabolic process at presynapse	IMP IMP: Inferred from mutant phenotype	29311685	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	21113145	MGI
acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	15249681	MGI
acts upstream of or within synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	12915482	MGI
acts upstream of or within synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	12915482	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24187134	MGI
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	29311685	MGI
is active in dopaminergic synapse	IEP IEP: Inferred from expression pattern	29311685	MGI
is active in dopaminergic synapse	IMP IMP: Inferred from mutant phenotype	29311685	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	23858059	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	11675120	MGI
located in nucleus	IDA IDA: Inferred from direct assay	24187134	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	18190519	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase parkin	Parkinson disease (autosomal recessive, juvenile) 2, parkin parkin protein

Prkn Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Prkn	Q9WVS6	Ywhah	Mus musculus	P68510	Anti Bait CoIP	16096643
Intra	Prkn	Q9WVS6	Ranbp2	Mus musculus	Q9ERU9	Anti Bait CoIP	16332688
Intra	Prkn	Q9WVS6	Chpf	Mus musculus	Q6IQX7-2	IF	22082830
Intra	Prkn	Q9WVS6	Chpf	Mus musculus	Q6IQX7-2	Anti Bait CoIP	22082830

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS25456	Prkn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11156	PRKN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18966	Prkn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkn	NCBI	NCBI:5071