Mpp2 - membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) Gene

Also Known as Dlg2; Dlgh2; Pals4; D11Bwg0652e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50997

Summary

Enables transmembrane transporter binding activity. A structural constituent of postsynaptic density. Involved in excitatory postsynaptic potential and long-term synaptic potentiation. Located in dendrite and glutamatergic synapse. Is anchored component of postsynaptic density membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; respiratory system; and retina. Orthologous to human MPP2 (MAGUK p55 scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mpp2 Products (8)

mRNA Protein Name
NM_001356324.2 NP_001343253.1 MAGUK p55 subfamily member 2 isoform 1
NM_001414216.1 NP_001401145.1 MAGUK p55 subfamily member 2 isoform 2
NM_001414217.1 NP_001401146.1 MAGUK p55 subfamily member 2 isoform 2
NM_001414218.1 NP_001401147.1 MAGUK p55 subfamily member 2 isoform 2
NM_001414219.1 NP_001401148.1 MAGUK p55 subfamily member 2 isoform 2
NM_001414220.1 NP_001401149.1 MAGUK p55 subfamily member 2 isoform 3
NM_001414221.1 NP_001401150.1 MAGUK p55 subfamily member 2 isoform 4
NM_016695.5 NP_057904.1 MAGUK p55 subfamily member 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12351654 MGI
enables structural constituent of postsynaptic density IDA
IDA: Inferred from direct assay
26880549 MGI
enables structural constituent of postsynaptic density IEP
IEP: Inferred from expression pattern
26880549 MGI
enables structural constituent of postsynaptic density IMP
IMP: Inferred from mutant phenotype
26880549 MGI
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
26880549 MGI
Biological Process GO Annotation Evidence References Source
involved in excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
26880549 MGI
involved in long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
26880549 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
26880549 MGI
is active in Schaffer collateral - CA1 synapse IEP
IEP: Inferred from expression pattern
26880549 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
26880549 MGI
located in dendrite membrane IDA
IDA: Inferred from direct assay
26880549 MGI
located in dendritic shaft IDA
IDA: Inferred from direct assay
26880549 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
26880549 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
26880549 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
26880549 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MAGUK p55 subfamily member 2

  • discs large homolog 2

  • p55 subfamily member of MAGUK family

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05064 FOXM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08623 MPP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19354 Mpp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25845 Mpp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpp2 NCBI NCBI:4355