TXNDC12 - thioredoxin domain containing 12 Gene

Also Known as AG1; AGR1; ERP16; ERP18; ERP19; TLP19; hAG-1; PDIA16; hTLP19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51060

About TXNDC12

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,020,131-52,056,171 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 12.7), thyroid (RPKM 11.7) and 25 other tissues.

Summary

This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]

TXNDC12 Products (1)

mRNA	Protein	Name
NM_015913.4	NP_056997.1	thioredoxin domain-containing protein 12 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein-disulfide reductase (glutathione) activity	IDA IDA: Inferred from direct assay	12761212	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	18628206	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	18628206	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	12761212	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TXNDC12 Protein Structure

Thioredoxin_7

0
100
172 a.a.

Protein Preferred Names	Protein Names
thioredoxin domain-containing protein 12	ER protein 18

TXNDC12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TXNDC12	O95881	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	TXNDC12	O95881	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	TXNDC12	O95881	CAMLG	Homo sapiens	P49069	Validated Y2H	32296183
Intra	TXNDC12	O95881	CAMLG	Homo sapiens	P49069	Y2H Prey Pooling	32296183
Intra	TXNDC12	O95881	CAMLG	Homo sapiens	P49069	Y2H Array	32296183
Intra	TXNDC12	O95881	DPF2	Homo sapiens	Q92785	Validated Y2H	32296183
Intra	TXNDC12	O95881	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	TXNDC12	O95881	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	TXNDC12	O95881	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	TXNDC12	O95881	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	25416956
Intra	TXNDC12	O95881	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	TXNDC12	O95881	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	TXNDC12	O95881	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	25416956
Intra	TXNDC12	O95881	SGTB	Homo sapiens	Q96EQ0	Y2H Array	25416956
Intra	TXNDC12	O95881	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	TXNDC12	O95881	KLHL2	Homo sapiens	O95198	Y2H Array	31515488
Intra	TXNDC12	O95881	KLHL2	Homo sapiens	O95198	Y2H Array	25416956
Intra	TXNDC12	O95881	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	TXNDC12	O95881	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	TXNDC12	O95881	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TXNDC12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71046	TXNDC12 Protein, Human (HEK293, His)	O95881 (H27-L168)	≥ 95%, as determined by reducing SDS-PAGE.

TXNDC12 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80006	AIF Antibody (YA636)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
HY-P86866	ERp18 Antibody (YA6559)	WB, IHC-P, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Discitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15290	TXNDC12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21267	Txndc12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27785	Txndc12 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TXNDC12	VGNC	VGNC:48011
Felis catus	TXNDC12	VGNC	VGNC:66725
Bos taurus	TXNDC12	VGNC	VGNC:36535
Rattus norvegicus	TXNDC12	RGD	RGD:1305960
Mus musculus	TXNDC12	MGD	MGI:1913323
Others	TXNDC12	NCBI