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ING4 - inhibitor of growth family member 4 Gene

Also Known as my036; p29ING4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51147

About ING4

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,650,301-6,663,119 (from NCBI)

This gene has 18 transcripts (splice variants), 222 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 15.7), endometrium (RPKM 14.9) and 25 other tissues.

Summary

This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

ING4 Products (6)

mRNA	Protein	Name
NM_001127582.2	NP_001121054.1	inhibitor of growth protein 4 isoform 9
NM_001127583.2	NP_001121055.1	inhibitor of growth protein 4 isoform 3
NM_001127584.2	NP_001121056.1	inhibitor of growth protein 4 isoform 4
NM_001127585.2	NP_001121057.1	inhibitor of growth protein 4 isoform 5
NM_001127586.2	NP_001121058.1	inhibitor of growth protein 4 isoform 6
NM_016162.4	NP_057246.2	inhibitor of growth protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to histone H3K14 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K12 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
NOT contributes to histone H4K16 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K5 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K8 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	16728974	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12750254	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16387653	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA replication-dependent chromatin disassembly	IDA IDA: Inferred from direct assay	16387653	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15029197	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12750254	GOA
involved in negative regulation of growth	IDA IDA: Inferred from direct assay	12750254	GOA
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA IDA: Inferred from direct assay	15251430	GOA
involved in protein acetylation	IDA IDA: Inferred from direct assay	12750254	GOA
involved in regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	16387653	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22144582	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	16387653	GOA
acts upstream of negative effect regulation of cell cycle G2/M phase transition	IDA IDA: Inferred from direct assay	15251430	GOA
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	22144582	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	16387653	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16387653	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15029197	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ING4 Protein Structure

ING

PHD

0
100
200
249 a.a.

Protein Preferred Names	Protein Names
inhibitor of growth protein 4	brain my036 protein

ING4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ING4	Q9UNL4	JADE2	Homo sapiens	A0A0C4DFT8	Y2H Array	32296183
Intra	ING4	Q9UNL4	JADE2	Homo sapiens	A0A0C4DFT8	Y2H Prey Pooling	32296183
Intra	ING4	Q9UNL4	JADE2	Homo sapiens	Q9NQC1	TAP	24981860
Intra	ING4	Q9UNL4	HNRNPD	Homo sapiens	Q14103	Pull Down	23603392
Intra	ING4	Q9UNL4	HNRNPD	Homo sapiens	Q14103	Anti Bait CoIP	23603392
Intra	ING4	Q9UNL4	HNRNPD	Homo sapiens	Q14103	Anti Tag CoIP	23603392
Intra	ING4	Q9UNL4	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	ING4	Q9UNL4	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	ING4	Q9UNL4	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	ING4	Q9UNL4	HNRNPD	Homo sapiens	Q14103-4	Pull Down	23603392
Intra	ING4	Q9UNL4	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ING4	Q9UNL4	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ING4	Q9UNL4	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ING4	Q9UNL4	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	ING4	Q9UNL4	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	ING4	Q9UNL4	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	ING4	Q9UNL4	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	ING4	Q9UNL4	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	ING4	Q9UNL4	NAV2	Homo sapiens	Q8IVL1	Y2H Prey Pooling	25416956
Intra	ING4	Q9UNL4	BEX3	Homo sapiens	Q00994	Y2H Array	32296183
Intra	ING4	Q9UNL4	BEX3	Homo sapiens	Q00994	Y2H Prey Pooling	32296183
Intra	ING4	Q9UNL4	H3C1	Homo sapiens	P68431	NMR	17157298
Intra	ING4	Q9UNL4	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	ING4	Q9UNL4	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	ING4	Q9UNL4	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ING4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74798	ING4 Protein, Human (His)	Q9UNL4-1 (M1-K249)	≥ 85%, as determined by reducing SDS-PAGE.

ING4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811302	ING4 Antibody	WB, IHC-P	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06810	ING4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19142	Ing4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25633	Ing4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ING4	VGNC	VGNC:30197
Mus musculus	ING4	MGD	MGI:107307
Macaca mulatta	ING4	VGNC	VGNC:73628
Felis catus	ING4	VGNC	VGNC:62923
Canis familiaris	ING4	VGNC	VGNC:103684
Rattus norvegicus	ING4	RGD	RGD:1309407
Others	ING4	NCBI