JADE2 - jade family PHD finger 2 Gene

Also Known as PHF15; JADE-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23338

About JADE2

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,523,952-134,583,227 (from NCBI)

This gene has 17 transcripts (splice variants), 212 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 11.1), ovary (RPKM 11.0) and 24 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Involved in histone acetylation. Located in nucleoplasm. Part of Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

JADE2 Products (8)

mRNA Protein Name
NM_001289984.2 NP_001276913.1 E3 ubiquitin-protein ligase Jade-2 isoform 1
NM_001289985.2 NP_001276914.1 E3 ubiquitin-protein ligase Jade-2 isoform 2
NM_001308143.2 NP_001295072.1 E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388185.1 NP_001375114.1 E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388186.1 NP_001375115.1 E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388187.1 NP_001375116.1 E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388188.1 NP_001375117.1 E3 ubiquitin-protein ligase Jade-2 isoform 5
NM_015288.6 NP_056103.4 E3 ubiquitin-protein ligase Jade-2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to histone H3K14 acetyltransferase activity IDA
IDA: Inferred from direct assay
16387653 GOA
enables histone H4K12 acetyltransferase activity IDA
IDA: Inferred from direct assay
16387653 GOA
NOT enables histone H4K16 acetyltransferase activity IDA
IDA: Inferred from direct assay
16387653 GOA
enables histone H4K5 acetyltransferase activity IDA
IDA: Inferred from direct assay
16387653 GOA
enables histone H4K8 acetyltransferase activity IDA
IDA: Inferred from direct assay
16387653 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of DNA biosynthetic process IDA
IDA: Inferred from direct assay
16387653 GOA
involved in regulation of DNA replication IDA
IDA: Inferred from direct assay
16387653 GOA
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
16387653 GOA
Cellular Component GO Annotation Evidence References Source
part of histone acetyltransferase complex IDA
IDA: Inferred from direct assay
16387653 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
16387653 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JADE2 Protein Structure

EPL1

EPL1: Enhancer of polycomb-like (42 - 176)

PHD_2

PHD_2: PHD-finger (214 - 247)

zf-HC5HC2H_2

zf-HC5HC2H_2: PHD-zinc-finger like domain (253 - 364)

  • 0
  • 200
  • 400
  • 600
  • 790 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase Jade-2

  • PHD finger protein 15

JADE2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
JADE2 Q9NQC1 ING4 Homo sapiens Q9UNL4
Y2H Array
20211142
Intra
JADE2 Q9NQC1 ING4 Homo sapiens Q9UNL4
Anti Tag CoIP
33961781
Intra
JADE2 Q9NQC1 ING5 Homo sapiens Q8WYH8
Y2H Prey Pooling
25416956
Intra
JADE2 Q9NQC1 ING5 Homo sapiens Q8WYH8
Anti Tag CoIP
33961781
Intra
JADE2 Q9NQC1 ING5 Homo sapiens Q8WYH8
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07010 JADE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta JADE2 VGNC VGNC:73641
Bos taurus JADE2 VGNC VGNC:30359
Mus musculus JADE2 MGD MGI:1924151
Rattus norvegicus JADE2 RGD RGD:1309152
Felis catus JADE2 VGNC VGNC:62996
Canis familiaris JADE2 VGNC VGNC:42170
Others JADE2 NCBI