RAB6B - RAB6B, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51560

About RAB6B

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:133,824,235-133,895,882 (from NCBI)

This gene has 7 transcripts (splice variants), 249 orthologues and 68 paralogues. Biased expression in brain (RPKM 76.4), heart (RPKM 6.6) and 1 other tissue.

Summary

Enables Myosin V binding activity. Predicted to be involved in Golgi vesicle transport; intracellular protein transport; and retrograde transport, endosome to Golgi. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

RAB6B Products (2)

mRNA	Protein	Name
NM_001363953.1	NP_001350882.1	ras-related protein Rab-6B isoform 2
NM_016577.4	NP_057661.3	ras-related protein Rab-6B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables myosin V binding	IPI IPI: Inferred from physical interaction	24006491	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23737971	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	26209634	GOA
involved in protein localization to Golgi membrane	IDA IDA: Inferred from direct assay	25492866	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	25492866	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB6B Protein Structure

Ras

0
100
208 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-6B	small GTP-binding protein

RAB6B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB6B	Q9NRW1	BICD2	Homo sapiens	Q8TD16-2	Y2H Prey Pooling	32296183
Intra	RAB6B	Q9NRW1	BICD2	Homo sapiens	Q8TD16-2	Y2H Array	32296183
Intra	RAB6B	Q9NRW1	RAP1GDS1	Homo sapiens	P52306-5	Y2H Prey Pooling	32296183
Intra	RAB6B	Q9NRW1	RAP1GDS1	Homo sapiens	P52306-5	Y2H Array	32296183
Intra	RAB6B	Q9NRW1	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RAB6B	Q9NRW1	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RAB6B	Q9NRW1	SH2B2	Homo sapiens	O14492-2	Y2H Prey Pooling	32296183
Intra	RAB6B	Q9NRW1	SH2B2	Homo sapiens	O14492-2	Y2H Array	32296183
Intra	RAB6B	Q9NRW1	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	27107012
Intra	RAB6B	Q9NRW1	COG6	Homo sapiens	Q9Y2V7	BFG-2H	27107012
Intra	RAB6B	Q9NRW1	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	RAB6B	Q9NRW1	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	RAB6B	Q9NRW1	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	RAB6B	Q9NRW1	PMM1	Homo sapiens	Q92871	Y2H Prey Pooling	32296183
Intra	RAB6B	Q9NRW1	PMM1	Homo sapiens	Q92871	Y2H Array	32296183
Intra	RAB6B	Q9NRW1	APBA1	Homo sapiens	Q02410-2	Y2H	23737971
Intra	RAB6B	Q9NRW1	APBA1	Homo sapiens	Q02410-2	Pull Down	23737971

Cross: Cross-species interaction Intra: Intraspecies interaction

RAB6B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84824	Rab6b Antibody (YA4521)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat
HY-P84824A	Rab6b Antibody (YA4521)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Cohen Syndrome	Pepper Syndrome COH1 Hypotonia, Obesity, And Prominent Incisors Coh Chs1, Formerly Norio Syndrome Obesity-Hypotonia Syndrome Prominent Incisors-Obesity-Hypotonia Syndrome Chs1 Hypotonia-Obesity-Prominent Incisors Stage 4s Neuroblastoma
Charcot-Marie-Tooth Disease, Recessive Intermediate A	Charcot-Marie-Tooth Disease Recessive Intermediate A CMTRIA Ri-Cmta Charcot-Marie-Tooth Disease, Recessive Intermediate, A Autosomal Recessive Intermediate Charcot-Marie-Tooth Disease Type A Charcot-Marie-Tooth Neuropathy Recessive Intermediate A Charcot-Marie-Tooth Neuropathy, Recessive Intermediate A Ri-Cmt Type A Charcot-Marie-Tooth Disease, Recessive, Intermediate Type, A
Corneal Dystrophy, Fleck	Fleck Corneal Dystrophy Fcd CFD Corneal Fleck Dystrophy Francois-Neetens Speckled Corneal Dystrophy Corneal Dystrophy, Francois-Neetens Speckled Or Flecked Corneal Dystrophy Francois-Neetens Speckled Or Flecked Dystrophy, Corneal, Fleck

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11575	RAB6B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25722	Rab6a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RAB6B	VGNC	VGNC:59057
Bos taurus	RAB6B	VGNC	VGNC:50013
Rattus norvegicus	RAB6B	RGD	RGD:1309958
Mus musculus	RAB6B	MGD	MGI:107283
Macaca mulatta	RAB6B	VGNC	VGNC:81547
Others	RAB6B	NCBI