Crebbp - CREB binding protein Gene

Also Known as CBP; RTS; RSTS

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54244

About Crebbp

Primary_assembly 10: 11,335,953-11,461,888 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 277 orthologues, 2 paralogues and is associated with 50 phenotypes. Biased expression in Thymus (RPKM 165.4), Spleen (RPKM 146.7) and 9 other tissues.

Summary

Enables several functions, including SMAD binding activity; peroxisome proliferator activated receptor binding activity; and transcription coactivator binding activity. Involved in several processes, including behavioral response to cocaine; long-term memory; and positive regulation of NIK/NF-kappaB signaling. Located in nuclear body. Part of transcription regulator complex. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Crebbp Products (1)

mRNA Protein Name
NM_133381.4 NP_596872.3 histone lysine acetyltransferase CREBBP

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
15598887 RGD
enables SMAD binding IPI
IPI: Inferred from physical interaction
16959941 RGD
enables histone acetyltransferase activity IDA
IDA: Inferred from direct assay
12477714 RGD
enables peroxisome proliferator activated receptor binding IDA
IDA: Inferred from direct assay
12095700 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16456924 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
16959941 RGD
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
15598887 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
24555056 RGD
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
32206715 RGD
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
18496732 RGD
involved in positive regulation of cell adhesion molecule production IMP
IMP: Inferred from mutant phenotype
20926146 RGD
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
32206715 RGD
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
20926146 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15598887 RGD
involved in protein modification process IDA
IDA: Inferred from direct assay
15632413 RGD
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14567501 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
15950780 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
24338162 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear body IDA
IDA: Inferred from direct assay
15488321 RGD
part of transcription regulator complex IDA
IDA: Inferred from direct assay
15632413 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Crebbp Protein Structure

zf-TAZ

zf-TAZ: pfam02135 (361 - 428)

KIX

KIX: pfam02172 (585 - 665)

PHA03247

PHA03247: cl33720 (681 - 1097)

COG5076

COG5076: cl34891 (941 - 1193)

Bromo_cbp_like

Bromo_cbp_like: cd05495 (1087 - 1194)

RING_CBP-p300

RING_CBP-p300: cd15802 (1206 - 1288)

PHD_CBP_p300

PHD_CBP_p300: cd15557 (1290 - 1321)

HAT_KAT11

HAT_KAT11: pfam08214 (1352 - 1659)

ZZ_CBP

ZZ_CBP: cd02337 (1715 - 1755)

zf-TAZ

zf-TAZ: pfam02135 (1782 - 1850)

Med15

Med15: cl26621 (1970 - 2424)

Creb_binding

Creb_binding: pfam09030 (2023 - 2124)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2454 a.a.
Protein Preferred Names Protein Names

histone lysine acetyltransferase CREBBP

  • protein-lysine acetyltransferase CREBBP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128875 CBP/p300-IN-10 Inhibitor 99.74% Unkown
HY-RS03155 CREBBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03156 Crebbp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-135236 OXFBD04 Inhibitor 98.99% Unkown
HY-114971 CREBBP-IN-1 / Unkown
HY-116237 CREBBP-IN-9 Inhibitor / Unkown
HY-122081 CPI-644 Inhibitor / Unkown
HY-128362 Ep300/CREBBP-IN-8 Inhibitor / Unkown
HY-128363 Ep300/CREBBP-IN-2 Inhibitor / Unkown
HY-128364 Ep300/CREBBP-IN-3 Inhibitor / Unkown
HY-128367 Ep300/CREBBP-IN-4 Inhibitor / Unkown
HY-RS03157 Crebbp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crebbp NCBI NCBI:1387