Ep300/CREBBP-IN-4
Ep300/CREBBP-IN-4 (Example 56) is a potent Ep300 and CREBBP inhibitor with IC50s of 0.024 and 0.064 μM, respectively. Ep300/CREBBP-IN-4 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2259641-42-2
- Formula: C23H22F3N5O3
- Molecular Weight:473.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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EP300 0.024 μM (IC50) |
CREBBP 0.064 μM (IC50) |
Ep300/CREBBP-IN-4 (Example 56) inhibits intracellular H3K27Ac activity with an IC50 of 0.020 μM[1].
Ep300/CREBBP-IN-4 (38 nM-10 mM; 3 days) inhibits LK2 and TE-8 cell growth with GI50s of 98.803 and 88.333 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LK2 and TE-8 cells
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Concentration:38 nM-10 mM
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Incubation Time:3 days
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Result:Inhibited LK2 and TE-8 cell growth with GI50s of 98.803 and 88.333 μM, respectively.
Chemical Information
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CAS No. 2259641-42-2
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Molecular Weight 473.45
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Formula C23H22F3N5O3
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SMILES
O=C(N1[C@H](C[C@H](C1)F)C(NC2=CC=C(NN=C3)C3=N2)=O)C4(C5=CC=C(C=C5)OC)CC(F)(C4)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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