2. Epigenetics
  3. Histone Acetyltransferase
  4. Ep300/CREBBP-IN-2

Ep300/CREBBP-IN-2 (Example 73) is a potent and orally active Ep300 and CREBBP inhibitor with IC50s of 0.052 and 0.148 μM, respectively. Ep300/CREBBP-IN-2 can be used for the research of cancer.

For research use only. We do not sell to patients.

Ep300/CREBBP-IN-2 Chemical Structure

Ep300/CREBBP-IN-2 Chemical Structure

CAS No. : 2259641-59-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Ep300/CREBBP-IN-2 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ep300/CREBBP-IN-2 (Example 73) is a potent and orally active Ep300 and CREBBP inhibitor with IC50s of 0.052 and 0.148 μM, respectively. Ep300/CREBBP-IN-2 can be used for the research of cancer[1].

IC50 & Target[1]

EP300

0.052 μM (IC50)

CREBBP

0.148 μM (IC50)

In Vitro

Ep300/CREBBP-IN-2 (Example 73) inhibits intracellular H3K27Ac activity with an IC50 of 0.070 μM[1].
Ep300/CREBBP-IN-2 (38 nM-10 mM; 3 days) inhibits LK2 and TE-8 cell growth with GI50s of 610.15 and 619.505 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ep300/CREBBP-IN-2 Related Antibodies

Cell Viability Assay[1]

Cell Line: LK2 and TE-8 cells
Concentration: 38 nM-10 mM
Incubation Time: 3 days
Result: Inhibited LK2 and TE-8 cell growth with GI50s of 610.15 and 619.505 μM, respectively.
In Vivo

Ep300/CREBBP-IN-2 (Example 73; 2 mg/kg/day; oral; twice daily for 9 days) inhibits tumor proliferation in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c-nu/nu mice, TE-8 cell subcutaneous transplant model[1]
Dosage: 2 mg/kg/day
Administration: Oral administration, twice a day for 9 days
Result: Inhibited tumor volume by 65%.
Molecular Weight

516.51

Formula

C26H27F3N4O4
CAS No.
SMILES

O=C([C@@H]1N(C(C2(C3=CC=C(OC)C=C3)CCC(F)(F)CC2)=O)C[C@H](F)C1)NC4=CC=C(NC(C5)=O)C5=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Ep300/CREBBP-IN-2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ep300/CREBBP-IN-22259641-59-1Histone AcetyltransferaseHATsHATH3K27AcLK2TE-8Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Ep300/CREBBP-IN-2
Cat. No.:
HY-128363
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.