Cpsf3 - cleavage and polyadenylation specificity factor 3 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54451

Summary

Enables 5'-3' exoribonuclease activity; RNA binding activity; and endoribonuclease activity. Involved in RNA phosphodiester bond hydrolysis, exonucleolytic and mRNA 3'-end processing by stem-loop binding activity and cleavage. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF3 (cleavage and polyadenylation specific factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Cpsf3 Products (3)

mRNA Protein Name
NM_001364372.1 NP_001351301.1 cleavage and polyadenylation specificity factor subunit 3 isoform 2
NM_001364373.1 NP_001351302.1 cleavage and polyadenylation specificity factor subunit 3 isoform 3
NM_018813.3 NP_061283.2 cleavage and polyadenylation specificity factor subunit 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5'-3' RNA exonuclease activity IDA
IDA: Inferred from direct assay
18955505 MGI
enables RNA binding IDA
IDA: Inferred from direct assay
18955505 MGI
enables RNA endonuclease activity IDA
IDA: Inferred from direct assay
18955505 MGI
Biological Process GO Annotation Evidence References Source
involved in mRNA 3'-end processing by stem-loop binding and cleavage IDA
IDA: Inferred from direct assay
18955505 MGI
Cellular Component GO Annotation Evidence References Source
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: Inferred from direct assay
16115198 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cleavage and polyadenylation specificity factor subunit 3

  • CPSF 73 kDa subunit

  • cleavage and polyadenylation specificity factor 73 kDa subunit

  • mRNA 3'-end-processing endonuclease CPSF-73

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-110133 JTE-607 Inhibitor 99.27% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153238 AN15368 Inhibitor / Unkown
HY-RS03118 CPSF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-110133A JTE-607 free base Inhibitor / Unkown
HY-112905 AN11736 Inhibitor / Unkown
HY-RS19423 Cpsf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25914 Cpsf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cpsf3 NCBI NCBI:51692