RNF43 - ring finger protein 43 Gene

Also Known as URCC; SSPCS; RNF124

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54894

About RNF43

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,352,500-58,417,534 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 105 phenotypes. Broad expression in duodenum (RPKM 7.1), colon (RPKM 6.1) and 24 other tissues.

Summary

The protein encoded by this gene is a RING-type E3 ubiquitin Ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of Frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

RNF43 Products (3)

mRNA Protein Name
NM_001305544.2 NP_001292473.1 E3 ubiquitin-protein ligase RNF43 isoform 1 precursor
NM_001305545.1 NP_001292474.1 E3 ubiquitin-protein ligase RNF43 isoform 2
NM_017763.6 NP_060233.3 E3 ubiquitin-protein ligase RNF43 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables frizzled binding IPI
IPI: Inferred from physical interaction
22895187 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18313049 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
22575959 GOA
Biological Process GO Annotation Evidence References Source
involved in Wnt receptor catabolic process IDA
IDA: Inferred from direct assay
22895187 GOA
involved in negative regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
22575959 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
22575959 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
22895187 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
22575959 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF43 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (271 - 312)

  • 0
  • 200
  • 400
  • 600
  • 783 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF43

  • RING-type E3 ubiquitin transferase RNF43

RNF43 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF43 Q68DV7 MYADM Homo sapiens Q96S97
Anti Tag CoIP
33961781
Intra
RNF43 Q68DV7 UBE2D2 Homo sapiens P62837
Enzymatic Study
18313049
Intra
RNF43 Q68DV7 UBE2D3 Homo sapiens P61077
Enzymatic Study
18313049
Intra
RNF43 Q68DV7 UBE2D3 Homo sapiens P61077
Y2H Array
19690564
Intra
RNF43 Q68DV7 AKAP8L Homo sapiens Q9ULX6
Y2H
18313049
Intra
RNF43 Q68DV7 AKAP8L Homo sapiens Q9ULX6
Anti Tag CoIP
18313049
Intra
RNF43 Q68DV7 UBB Homo sapiens P0CG47
Anti Tag CoIP
18313049
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RNF43 Proteins

Cat. No. Product Name Accession Purity
HY-P76007 RNF43 Protein, Human (HEK293, Fc) Q68DV7-1 (G24-Y197) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P76008 RNF43 Protein, Human (HEK293, His) Q68DV7-1/NP_060233.3 (G24-Y197) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Sessile Serrated Polyposis Cancer Syndrome

  • SSPCS

  • Serrated Polyposis Syndrome

  • Hyperplastic Polyposis Syndrome
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Uterine Corpus Endometrial Carcinoma
Pancreatoblastoma
Hereditary Mixed Polyposis Syndrome

  • Hmps
Tetraamelia Syndrome

  • Tetra-Amelia Syndrome

  • Tetraamelia-Multiple Malformations Syndrome

  • Tetra-Amelia

  • Tetra-Amelia, Autosomal Recessive

  • Tetraamelia, Autosomal Recessive

  • Total Amelia

  • Zimmer Phocomelia

  • Tetams

  • Zimmer Taub Sova Syndrome
Ovarian Cystadenocarcinoma

  • Cystadenocarcinoma Of Ovary

  • Cystadenocarcinoma Of The Ovary
Pancreatic Mucinous Cystadenoma

  • Pancreatic Mucinous Cystic Neoplasm

  • Pancreatic Mucinous-Cystic Neoplasm
Ovarian Serous Cystadenocarcinoma

  • Serous Cystadenoma

  • Cystadenoma Serous

  • Cystadenoma, Serous
Ovary Adenocarcinoma

  • Ovarian Adenocarcinoma

  • Adenocarcinoma Of The Ovary

  • Ovarian Adenoacanthoma

  • Adenocarcinoma Of Ovary
Lynch Syndrome

  • Hereditary Nonpolyposis Colon Cancer

  • Hereditary Nonpolyposis Colorectal Cancer

  • Hereditary Nonpolyposis Colorectal Carcinoma

  • Hereditary Nonpolyposis Colorectal Neoplasms

  • Familial Nonpolyposis Colon Cancer

  • Hnpcc

  • Coca 1

  • Hereditary Defective Mismatch Repair Syndrome

  • Hereditary Non-Polyposis Colon Cancer

  • Hereditary Non-Polyposis Colon Cancer Syndrome

  • Hereditary Non-Polyposis Colorectal Cancer

  • Hereditary Non-Polyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colon Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Neoplasm

  • Hnpcc - Hereditary Nonpolyposis Colon Cancer

  • Cancer Family Syndrome

  • Familial Nonpolyposis Colorectal Cancer

  • Colon Cancer, Familial Nonpolyposis

  • Colorectal Neoplasms, Hereditary Nonpolyposis

  • Cancer, Colorectal, Nonpolyposis, Hereditary

  • Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Colonic Benign Neoplasm

  • Colon Neoplasm

  • Colonic Mass

  • Colonic Tumor

  • Neoplasm Of Colon

  • Neoplasm Of The Colon

  • Colonic Neoplasms

  • Colon Cancer

  • Colon Carcinoma Nos

  • Colonic Cancer

  • Metastatic Colon Cancer Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10810 QPH-FR Inhibitor 99.54% Unkown
HY-RS12093 RNF43 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17844 Rnf43 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24312 Rnf43 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992297 Anti-RNF43 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RNF43 RGD RGD:1305204
Mus musculus RNF43 MGD MGI:2442609
Macaca mulatta RNF43 VGNC VGNC:99221
Canis familiaris RNF43 VGNC VGNC:45671
Felis catus RNF43 VGNC VGNC:99434
Bos taurus RNF43 VGNC VGNC:34068
Others RNF43 NCBI