DUS2 - dihydrouridine synthase 2 Gene

Homo sapiens

Also known as SMM1; DUS2L; URLC8

Gene ID: 54920 | Gene type: protein coding

About DUS2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,023,284-68,079,320 (from NCBI)

This gene has 16 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in testis (RPKM 12.7), lymph node (RPKM 5.7) and 24 other tissues.

Summary

This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

DUS2 Products(3)

mRNA	Protein	Name
NM_001271762.2	NP_001258691.1	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1
NM_001271763.2	NP_001258692.1	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2
NM_017803.5	NP_060273.1	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1

DUS2 Protein Structure

Dus

dsrm

0
100
200
300
400
493 a.a.

Protein Preferred Names

Protein Names

tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

SMM1 homolog

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04048	DUS2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DUS2	VGNC	VGNC:61658
Rattus norvegicus	DUS2	RGD	RGD:1305612
Macaca mulatta	DUS2	VGNC	VGNC:71908
Canis familiaris	DUS2	VGNC	VGNC:40124
Mus musculus	DUS2	MGD	MGI:1913619
Bos taurus	DUS2	VGNC	VGNC:28246