DUS2 - dihydrouridine synthase 2 Gene

Also Known as SMM1; DUS2L; URLC8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54920

About DUS2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,023,284-68,079,320 (from NCBI)

This gene has 16 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in testis (RPKM 12.7), lymph node (RPKM 5.7) and 24 other tissues.

Summary

This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified Bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

DUS2 Products (3)

mRNA Protein Name
NM_001271762.2 NP_001258691.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1
NM_001271763.2 NP_001258692.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2
NM_017803.5 NP_060273.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1

DUS2 Protein Structure

Dus

Dus: Dihydrouridine synthase (Dus) (15 - 329)

dsrm

dsrm: Double-stranded RNA binding motif (370 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
Protein Preferred Names Protein Names

tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

  • SMM1 homolog

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04048 DUS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DUS2 VGNC VGNC:61658
Rattus norvegicus DUS2 RGD RGD:1305612
Macaca mulatta DUS2 VGNC VGNC:71908
Canis familiaris DUS2 VGNC VGNC:40124
Mus musculus DUS2 MGD MGI:1913619
Bos taurus DUS2 VGNC VGNC:28246
Others DUS2 NCBI