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SSH3 - slingshot protein phosphatase 3 Gene

Also Known as SSH3L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54961

About SSH3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,303,530-67,312,592 (from NCBI)

This gene has 11 transcripts (splice variants), 193 orthologues and 30 paralogues. Ubiquitous expression in urinary bladder (RPKM 17.7), prostate (RPKM 14.2) and 25 other tissues.

Summary

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]

SSH3 Products (1)

mRNA	Protein	Name
NM_017857.4	NP_060327.3	protein phosphatase Slingshot homolog 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSH3 Protein Structure

DEK_C

DSPc

0
200
400
600
659 a.a.

Protein Preferred Names	Protein Names
protein phosphatase Slingshot homolog 3	SSH-3L

Related Diseases

Diseases	Alias
Epilepsy, Idiopathic Generalized 17	Febrile Seizures, Familial, 2 EIG17 Familial Febrile Seizures 2 FEB2 Epilepsy, Idiopathic Generalized, Susceptibility To, 17 Familial Febrile Convulsions 2 Convulsions, Familial Febrile, 2
Endosteal Hyperostosis, Autosomal Dominant	Osteosclerosis Worth Syndrome Osteosclerosis, Autosomal Dominant Hyperostosis, Endosteal Endosteal Hyperostosis, Worth Type Worth Disease Autosomal Dominant Endosteal Hyperostosis Autosomal Dominant Osteosclerosis, Worth Type Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus Autosomal Dominant Osteosclerosis Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus Worth'S Syndrome Worth Type Autosomal Dominant Osteosclerosis Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus Osteosclerosis, Autosomal Dominant, Worth Type WENHY Endosteal Hyperostosis Autosomal Dominant Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus Osteosclerosis Autosomal Dominant Acquired Osteosclerosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13811	SSH3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SSH3	RGD	RGD:1308679
Felis catus	SSH3	VGNC	VGNC:65705
Canis familiaris	SSH3	VGNC	VGNC:46833
Macaca mulatta	SSH3	VGNC	VGNC:78019
Mus musculus	SSH3	MGD	MGI:2683546
Bos taurus	SSH3	VGNC	VGNC:35314
Others	SSH3	NCBI