USP40 - ubiquitin specific peptidase 40 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55230

About USP40

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,475,526-233,566,782 (from NCBI)

This gene has 17 transcripts (splice variants), 191 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 7.5), thyroid (RPKM 6.8) and 25 other tissues.

Summary

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating Enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating Enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

USP40 Products (11)

mRNA Protein Name
NM_001365479.2 NP_001352408.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 1
NM_001382295.1 NP_001369224.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 1
NM_001382296.1 NP_001369225.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 3
NM_001382297.1 NP_001369226.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 4
NM_001382298.1 NP_001369227.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 5
NM_001382299.1 NP_001369228.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 6
NM_001382300.1 NP_001369229.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 7
NM_001382301.1 NP_001369230.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 8
NM_001382302.1 NP_001369231.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 9
NM_001382303.1 NP_001369232.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 10
NM_018218.4 NP_060688.2 ubiquitin carboxyl-terminal hydrolase 40 isoform 2

USP40 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (41 - 323)

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  • 1235 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 40

  • deubiquitinating enzyme 40

Related Diseases

Diseases Alias
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15552 USP40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20512 Usp40 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27021 Usp40 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus USP40 VGNC VGNC:52845
Mus musculus USP40 MGD MGI:2443184
Macaca mulatta USP40 VGNC VGNC:79226
Rattus norvegicus USP40 RGD RGD:1309613
Others USP40 NCBI