2. Gene
  3. USP40 - ubiquitin specific peptidase 40 Gene

USP40 - ubiquitin specific peptidase 40 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 55230 | Gene type: protein coding

About USP40

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,475,526-233,566,782 (from NCBI)

This gene has 17 transcripts (splice variants), 191 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 7.5), thyroid (RPKM 6.8) and 25 other tissues.

Summary

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

USP40 Products(11)

mRNA Protein Name
NM_001365479.2 NP_001352408.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 1
NM_001382295.1 NP_001369224.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 1
NM_001382296.1 NP_001369225.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 3
NM_001382297.1 NP_001369226.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 4
NM_001382298.1 NP_001369227.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 5
NM_001382299.1 NP_001369228.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 6
NM_001382300.1 NP_001369229.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 7
NM_001382301.1 NP_001369230.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 8
NM_001382302.1 NP_001369231.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 9
NM_001382303.1 NP_001369232.1 ubiquitin carboxyl-terminal hydrolase 40 isoform 10
NM_018218.4 NP_060688.2 ubiquitin carboxyl-terminal hydrolase 40 isoform 2

USP40 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (41 - 323)

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  • 1235 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 40

deubiquitinating enzyme 40

Related Diseases

Diseases Alias
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15552 USP40 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus USP40 VGNC VGNC:52845
Mus musculus USP40 MGD MGI:2443184
Macaca mulatta USP40 VGNC VGNC:79226
Rattus norvegicus USP40 RGD RGD:1309613