UBE2W - ubiquitin conjugating enzyme E2 W Gene

Also Known as UBC16; UBC-16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55284

About UBE2W

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,780,096-73,878,862 (from NCBI)

This gene has 9 transcripts (splice variants), 217 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 6.0), thyroid (RPKM 4.9) and 25 other tissues.

Summary

This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) Enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

UBE2W Products (3)

mRNA	Protein	Name
NM_001001481.4	NP_001001481.3	ubiquitin-conjugating enzyme E2 W isoform 1
NM_001271015.3	NP_001257944.2	ubiquitin-conjugating enzyme E2 W isoform 3
NM_018299.6	NP_060769.5	ubiquitin-conjugating enzyme E2 W isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19549727	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: Inferred from direct assay	23509263	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19111657	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19111657	GOA
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	21229326	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	35893676	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	35927303	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	35927303	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	19111657	GOA
involved in protein monoubiquitination	IMP IMP: Inferred from mutant phenotype	21229326	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2W Protein Structure

UQ_con

0
100
151 a.a.

Protein Preferred Names	Protein Names
ubiquitin-conjugating enzyme E2 W	E2 ubiquitin-conjugating enzyme W

UBE2W Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBE2W	Q96B02	PSTPIP1	Homo sapiens	O43586	Validated Y2H	25416956
Intra	UBE2W	Q96B02	PSTPIP1	Homo sapiens	O43586	Y2H Array	25416956
Intra	UBE2W	Q96B02	PSTPIP1	Homo sapiens	O43586	Y2H	21516116
Intra	UBE2W	Q96B02	MARCHF5	Homo sapiens	Q9NX47	Y2H Array	19549727
Intra	UBE2W	Q96B02	MARCHF5	Homo sapiens	Q9NX47	Y2H Array	31515488
Intra	UBE2W	Q96B02	MARCHF5	Homo sapiens	Q9NX47	Validated Y2H	25416956
Intra	UBE2W	Q96B02	MARCHF5	Homo sapiens	Q9NX47	Y2H Array	25416956
Intra	UBE2W	Q96B02	RNF5	Homo sapiens	Q99942	Validated Y2H	25416956
Intra	UBE2W	Q96B02	RNF5	Homo sapiens	Q99942	Y2H Array	25416956
Intra	UBE2W	Q96B02	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	UBE2W	Q96B02	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	UBE2W	Q96B02	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	UBE2W	Q96B02	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2W Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77272	UBE2W Protein, Human (His)	Q96B02-1 (M1-C151)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Brachydactyly, Type E2	Brachydactyly Type E2 BDE2 Brachydactyly E2
Spinocerebellar Ataxia, Autosomal Recessive 16	Autosomal Recessive Spinocerebellar Ataxia 16 SCAR16 Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency Spinocerebellar Ataxia Autosomal Recessive Type 16 Spinocerebellar Ataxia, Autosomal Recessive, 16 Ataxia, Spinocerebellar, Autosomal Recessive, Type 16

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15366	UBE2W Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20124	Ube2w Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26628	Ube2w Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBE2W	RGD	RGD:6503620
Macaca mulatta	UBE2W	VGNC	VGNC:99479
Mus musculus	UBE2W	MGD	MGI:1914049
Others	UBE2W	NCBI