EDEM2 - ER degradation enhancing alpha-mannosidase like protein 2 Gene

Also Known as C20orf31; C20orf49; bA4204.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55741

About EDEM2

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,115,364-35,147,336 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 13.1), lung (RPKM 12.7) and 25 other tissues.

Summary

In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the Proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008]

EDEM2 Products (2)

mRNA Protein Name
NM_001145025.2 NP_001138497.1 ER degradation-enhancing alpha-mannosidase-like protein 2 isoform 2 precursor
NM_018217.3 NP_060687.2 ER degradation-enhancing alpha-mannosidase-like protein 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA
IDA: Inferred from direct assay
15537790 GOA
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
IMP: Inferred from mutant phenotype
25092655 GOA
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
15537790 GOA
involved in mannoprotein catabolic process IMP
IMP: Inferred from mutant phenotype
25092655 GOA
involved in positive regulation of retrograde protein transport, ER to cytosol IGI
IGI: Inferred from genetic interaction
24200403 GOA
involved in positive regulation of retrograde protein transport, ER to cytosol IMP
IMP: Inferred from mutant phenotype
24200403 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15537790 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EDEM2 Protein Structure

Glyco_hydro_47

Glyco_hydro_47: Glycosyl hydrolase family 47 (42 - 481)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 578 a.a.
Protein Preferred Names Protein Names

ER degradation-enhancing alpha-mannosidase-like protein 2

  • ER degradation enhancer, mannosidase alpha-like 2

Recombinant EDEM2 Proteins

Cat. No. Product Name Accession Purity
HY-P76897 EDEM2 Protein, Human (HEK293, His) AAH01371.1 (A22-K492) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04158 EDEM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20395 Edem2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26904 Edem2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EDEM2 MGD MGI:1915540
Bos taurus EDEM2 VGNC VGNC:28323
Canis familiaris EDEM2 VGNC VGNC:40195
Macaca mulatta EDEM2 VGNC VGNC:72050
Rattus norvegicus EDEM2 RGD RGD:1303074
Felis catus EDEM2 VGNC VGNC:61723
Others EDEM2 NCBI