ADAP2 - ArfGAP with dual PH domains 2 Gene

Also Known as CENTA2; cent-b; HSA272195

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55803

About ADAP2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,921,945-30,959,322 (from NCBI)

This gene has 11 transcripts (splice variants), 250 orthologues and 28 paralogues. Broad expression in spleen (RPKM 10.3), placenta (RPKM 9.9) and 23 other tissues.

Summary

The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016]

ADAP2 Products (4)

mRNA	Protein	Name
NM_001346712.2	NP_001333641.1	arf-GAP with dual PH domain-containing protein 2 isoform 1
NM_001346714.2	NP_001333643.1	arf-GAP with dual PH domain-containing protein 2 isoform 3
NM_001346716.2	NP_001333645.1	arf-GAP with dual PH domain-containing protein 2 isoform 4
NM_018404.3	NP_060874.1	arf-GAP with dual PH domain-containing protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables inositol 1,3,4,5 tetrakisphosphate binding	IDA IDA: Inferred from direct assay	14690521	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	14690521	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20098747	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in heart development	IEP IEP: Inferred from expression pattern	16138909	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14690521	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	14690521	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAP2 Protein Structure

ArfGap

PH_11

0
100
200
300
381 a.a.

Protein Preferred Names	Protein Names
arf-GAP with dual PH domain-containing protein 2	centaurin beta

Related Diseases

Diseases	Alias
Chromosome 17q11.2 Deletion Syndrome	Nf1 Microdeletion Syndrome 17q11 Microdeletion Syndrome Neurofibromatosis Type 1 Microdeletion Syndrome Van Asperen Syndrome Del(17)(Q11) Monosomy 17q11 Chromosome 17q11.2 Deletion Syndrome, 1.4mb
Neurofibromatosis-Noonan Syndrome	NFNS Neurofibromatosis Type 1 Neurofibromatosis With Noonan Phenotype Nf1 Von Recklinghausen Disease Neurofibromatosis Type 1-Noonan Syndrome Noonan Neurofibromatosis Syndrome Recklinghausen'S Disease Noonan-Neurofibromatosis Syndrome Fibromatosis Multiple Non Ossifying Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots Jaffe Campanacci Syndrome Type 1 Neurofibromatosis Neurofibromatosis 1 Peripheral Neurofibromatosis Recklinghausen Disease, Nerve Jaffe-Campanacci Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00316	ADAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADAP2	RGD	RGD:708487
Canis familiaris	ADAP2	VGNC	VGNC:37611
Felis catus	ADAP2	VGNC	VGNC:59605
Macaca mulatta	ADAP2	VGNC	VGNC:69430
Mus musculus	ADAP2	MGD	MGI:2663075
Bos taurus	ADAP2	VGNC	VGNC:25634
Others	ADAP2	NCBI