Mpc1 - mitochondrial pyruvate carrier 1 Gene

Also Known as Brp44l; 0610006G08Rik; 3830411I18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 55951

Summary

Contributes to pyruvate transmembrane transporter activity. Acts upstream of or within cellular response to leukemia inhibitory factor; mitochondrial acetyl-CoA biosynthetic process from pyruvate; and mitochondrial pyruvate transmembrane transport. Located in mitochondrial inner membrane. Is expressed in several structures, including adrenal gland; hemolymphoid system; nervous system; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in mitochondrial pyruvate carrier deficiency. Orthologous to human MPC1 (mitochondrial pyruvate carrier 1). [provided by Alliance of Genome Resources, Apr 2022]

Mpc1 Products (3)

mRNA Protein Name
NM_001364918.1 NP_001351847.1 mitochondrial pyruvate carrier 1 isoform 2
NM_001364919.1 NP_001351848.1 mitochondrial pyruvate carrier 1 isoform 3
NM_018819.5 NP_061289.1 mitochondrial pyruvate carrier 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables pyruvate transmembrane transporter activity IDA
IDA: Inferred from direct assay
22628554 MGI
contributes to pyruvate transmembrane transporter activity IGI
IGI: Inferred from genetic interaction
22628554 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within acetyl-CoA biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
22628558 MGI
involved in acetyl-CoA biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
22628558 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within mitochondrial pyruvate transmembrane transport IGI
IGI: Inferred from genetic interaction
22628554 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
22628554 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial pyruvate carrier 1

  • apoptosis-regulating basic protein

  • brain protein 44-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138559 GW604714X Inhibitor 98.49% Unkown
HY-RS08606 MPC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24967 Mpc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18485 Mpc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpc1 NCBI NCBI:51660