Cxcl13 - chemokine (C-X-C motif) ligand 13 Gene

Also Known as BLC; Angie; BCA-1; BLR1L; ANGIE2; Scyb13; 4631412M08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 55985

Summary

Enables CXCR5 Chemokine Receptor binding activity and chemokine activity. Involved in several processes, including B cell chemotaxis across high endothelial venule; activation of GTPase activity; and lymph node development. Located in extracellular space. Is expressed in Peyer's patch; aorta; central nervous system; and retina. Orthologous to human CXCL13 (C-X-C motif chemokine ligand 13). [provided by Alliance of Genome Resources, Apr 2022]

Cxcl13 Products (1)

mRNA Protein Name
NM_018866.2 NP_061354.1 C-X-C motif chemokine 13 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CXCR5 chemokine receptor binding IDA
IDA: Inferred from direct assay
9463416 MGI
enables chemokine activity IDA
IDA: Inferred from direct assay
15972452 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell chemotaxis IMP
IMP: Inferred from mutant phenotype
15972452 MGI
involved in B cell chemotaxis across high endothelial venule IDA
IDA: Inferred from direct assay
15972452 MGI
involved in activation of GTPase activity IDA
IDA: Inferred from direct assay
15972452 MGI
involved in lymph node development IDA
IDA: Inferred from direct assay
19783990 MGI
acts upstream of or within lymph node development IMP
IMP: Inferred from mutant phenotype
12732660 MGI
involved in lymphocyte chemotaxis across high endothelial venule IMP
IMP: Inferred from mutant phenotype
15972452 MGI
involved in positive regulation of cell-cell adhesion mediated by integrin IDA
IDA: Inferred from direct assay
15972452 MGI
involved in positive regulation of integrin activation IDA
IDA: Inferred from direct assay
15972452 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
23460747 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-X-C motif chemokine 13

  • B lymphocyte chemoattractant

  • CXC chemokine BLC

  • small inducible cytokine subfamily B (Cys-X-Cys), member 13

  • small-inducible cytokine B13

Recombinant Cxcl13 Proteins

Cat. No. Product Name Accession Purity
HY-P77911 BCA-1/CXCL13 Protein, Mouse (HEK293, His) O55038 (I22-A109) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77912 BCA-1/CXCL13 Protein, Mouse (HEK293, Fc) O55038 (I22-A109) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99459 Baminercept Inhibitor 99.97% Phase 2
HY-163480 PF-06835375 Antagonist 97.71% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175606 EVT0185 Inhibitor 99.39% Unkown
HY-182774 YU241279 Inhibitor 99.58% Unkown
HY-182671 SRX3305 / Unkown
HY-RS03387 CXCL13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16602 Cxcl13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23036 Cxcl13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991567 VX5 Modulator 96.19% Unkown
HY-P992222 Anti-CXCL13 Antibody / Unkown
HY-P992476 TJX7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcl13 NCBI NCBI:10563