CXCL13 - C-X-C motif chemokine ligand 13 Gene

Also Known as BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10563

About CXCL13

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:77,511,753-77,611,834 (from NCBI)

This gene has 3 transcripts (splice variants), 118 orthologues and 12 paralogues. Biased expression in lymph node (RPKM 245.2), spleen (RPKM 177.4) and 3 other tissues.

Summary

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

CXCL13 Products (2)

mRNA	Protein	Name
NM_001371558.1	NP_001358487.1	C-X-C motif chemokine 13 precursor
NM_006419.3	NP_006410.1	C-X-C motif chemokine 13 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CCR10 chemokine receptor binding	IDA IDA: Inferred from direct assay	10706668	GOA
enables CXCR3 chemokine receptor binding	IPI IPI: Inferred from physical interaction	11554781	GOA
enables CXCR5 chemokine receptor binding	IDA IDA: Inferred from direct assay	9463416	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	11554781	GOA
enables fibroblast growth factor binding	IDA IDA: Inferred from direct assay	11708770	GOA
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	11708770	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	11708770	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	11554781	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell chemotaxis	IDA IDA: Inferred from direct assay	9463416	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	11554781	GOA
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	11554781	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	17562761	GOA
involved in endothelial cell chemotaxis to fibroblast growth factor	IDA IDA: Inferred from direct assay	11708770	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
involved in negative regulation of endothelial cell chemotaxis to fibroblast growth factor	IDA IDA: Inferred from direct assay	11708770	GOA
involved in positive regulation of T cell chemotaxis	IDA IDA: Inferred from direct assay	11554781	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	11554781	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	17562761	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL13 Protein Structure

IL8

0
100
109 a.a.

Protein Preferred Names	Protein Names
C-X-C motif chemokine 13	B-cell chemoattractant

Recombinant CXCL13 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7131	BCA-1/CXCL13 Protein, Human	O43927 (V23-P109)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700044AF	Animal-Free BCA-1/CXCL13 Protein, Human (His)	O43927 (V23-R94)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Angioimmunoblastic T-Cell Lymphoma	Immunoblastic Lymphadenopathy Lymphogranulomatosis X T-Cell Lymphoma, Aild Type Aitl Ailt Angioimmunoblastic Lymphadenopathy Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia] Angioimmunoblastic Lymphoma
Neurosyphilis	Syphilis Of Central Nervous System Late Syphilis Of Central Nervous System Nos Late Syphilis Of The Central Nervous System Gumma Of Central Nervous System Neurosyphilis Gumma Neurosyphilitic Gumma Syphilis Of Central Nervous System Nos Syphilitic Gumma Of Central Nervous System Tertiary Central Nervous System Syphilis
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral
Primary Central Nervous System Lymphoma	Pcnsl Primary Cns Lymphoma Primary Brain Lymphoma Primary Lymphoma, Cns Primary Cerebral Lymphoma
Asymptomatic Neurosyphilis	Neurosyphilis Neurosyphilis, Asymptomatic
Tabes Dorsalis	Posterior Spinal Sclerosis Tabes Dorsalis - Neurosyphilis Syphilitic Myelopathy
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Meningovascular Neurosyphilis
Tertiary Neurosyphilis	Late Neurosyphilis Late Syphilis Of Central Nervous System Nos
Neuromyelitis Optica	Devic Disease Devic Syndrome Neuromyelitis Optica Spectrum Disorder Devic'S Disease Devic'S Syndrome Devic'S Neuromyelitis Optica Nmo Nmo Spectrum Disorder Neuromyelitis Optica Spectrum Disorders Devic Neuromyelitis Optica Optic-Spinal Ms Opticospinal Ms Nmosd Opticospinal Multiple Sclerosis Devic Ophthalmoneuromyelitis Optic Neuromyelitis Optic Neuroencephalomyelopathy Nmo - [Neuromyelitis Optica] Optic Neuritis With Demyelination
Endometritis
Castleman Disease	Angiofollicular Ganglionic Hyperplasia Angiofollicular Lymph Hyperplasia Giant Lymph Node Hyperplasia Castleman'S Disease Angiofollicular Lymph Node Hyperplasia Lymphoid Hamartoma Benign Giant Lymphoma Angiolymphoid Hyperplasia
Syphilitic Meningitis	Syphilitic Aseptic Meningitis Meningeal Syphilis Meningitis, Syphilitic
Tertiary Syphilis	Late Syphilis Syphilis, Tertiary Late Syphilis, Unspecified Late Tertiary Syphilis
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Optic Neuritis	Inflammatory Optic Neuropathy
Sjogren Syndrome	Sicca Syndrome Sjogren'S Syndrome Sjögren Syndrome Sjogren-Gougerot Syndrome Keratoconjunctivitis Sicca Sjögren'S Syndrome Xerodermosteosis Dacryosialoadenopathia Atrophicans Gougerot-Houwer-Sjogren Syndrome Gougerot-Sjogren Syndrome Keratoconjunctivitis Sicca-Xerostomia Secreto-Inhibitor-Xerodermostenosis Primary Sjogren Syndrome Primary Sjogren-Gougerot Syndrome Sjogrens Syndrome Primary Sjogrens Syndrome Dry Eye Syndromes
Cryoglobulinemia	Cryoimmunoglobulinaemia
B-Lymphoblastic Leukemia/Lymphoma	B Lymphoblastic Leukemia/Lymphoma B-All Precursor B Lymphoblastic Lymphoma/Leukemia C-All Lymphoblastic Lymphoma, Nos Common Precursor B All Lymphoblastic B-Cell Lymphoma Pro-B All B-Precursor Lymphoma Lbl - [Lymphoblastic Lymphoma]
Eye Lymphoma	Malignant Lymphoma Of Eye Lymphoma Of Eye
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Meningitis	Streptococcal Meningitis Acute Streptococcal Meningitis Staphylococcal Meningitis Adenoviral Meningitis Influenza Meningitis Influenzal Meningitis Meningitis Due To H. Influenzae Cryptococcal Meningitis Fungal Meningitis Due To Cryptococcus Neoformans Cryptococcosis Meningitis Cryptococcus Meningitis Cryptococcal Meningoencephalitis Meningitis Due To Cryptococcus Mumps Virus Meningitis Mumps Meningitis
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Intraocular Lymphoma	Primary Intraocular Lymphoma Piol Primary Intraocular Non-Hodgkin Lymphoma Primary Intraocular Non-Hodgkin Malignant Lymphoma
Latent Syphilis	Syphilis, Latent
Acrodermatitis Chronica Atrophicans	Acrodermatitis Atrophicans Chronica Herxheimer Disease Primary Diffuse Atrophy
Secondary Syphilis	Syphilis, Secondary Secondary Syphilis Of Viscera Or Bone
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Autoimmune Disease Of Exocrine System
Central Nervous System Lymphoma	Microglioma Primary Cns Lymphoma Cns Lymphoma Primary Central Nervous System Lymphoma
Central Nervous System Hematologic Cancer	Cns Hematopoietic Tumor Hematopoietic Neoplasm Of Central Nervous System Central Nervous System Hematopoietic Neoplasm
Viral Meningitis	Meningitis Viral Meningitis, Viral Viral Meningitis Nec
Polyclonal Hypergammaglobulinemia	Polyclonal Gammopathy
Primary Progressive Multiple Sclerosis	Ppms Primary-Progressive Ms Multiple Sclerosis, Primary Progressive
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Tick-Borne Encephalitis	Siberian Tick-Borne Encephalitis Encephalitis, Tick-Borne Central European Encephalitis Far Eastern Tbe Russian Spring-Summer Encephalitis Taiga Encephalitis West-Siberian Encephalitis Western European Tick-Borne Encephalitis Tbe Encephalitis Tick-Borne Encephalitis, Central European Encephalitis, Far Eastern Russian
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Sodoku Disease	Spirillosis Sodoku Spirillary Fever Rat-Bite Fever Rat-Bite Fever Due To Spirillum Minus Spirillary Rat-Bite Fever Sokosho

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-163480	PF-06835375	Antagonist	97.71%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175606	EVT0185	Inhibitor	99.39%	Unkown
HY-182774	YU241279	Inhibitor	99.58%	Unkown
HY-182671	SRX3305		/	Unkown
HY-RS03387	CXCL13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16602	Cxcl13 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23036	Cxcl13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99459	Baminercept	Inhibitor	99.97%	Unkown
HY-P991567	VX5	Modulator	96.19%	Unkown
HY-P992222	Anti-CXCL13 Antibody		/	Unkown
HY-P992476	TJX7	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CXCL13	VGNC	VGNC:71393
Canis familiaris	CXCL13	VGNC	VGNC:39747
Rattus norvegicus	CXCL13	RGD	RGD:1564256
Mus musculus	CXCL13	MGD	MGI:1888499
Felis catus	CXCL13	VGNC	VGNC:78478
Bos taurus	CXCL13	VGNC	VGNC:27849
Others	CXCL13	NCBI