ACRV1 - acrosomal vesicle protein 1 Gene

Also Known as SP-10; SPACA2; D11S4365

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56

About ACRV1

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,671,522-125,680,847 (from NCBI)

This gene has 4 transcripts (splice variants), 91 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 39.8).

Summary

This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

ACRV1 Products (4)

mRNA Protein Name
NM_001612.6 NP_001603.1 acrosomal protein SP-10 isoform a precursor
NM_020069.5 NP_064454.1 acrosomal protein SP-10 isoform b precursor
NM_020107.5 NP_064492.1 acrosomal protein SP-10 isoform c precursor
NM_020108.5 NP_064493.1 acrosomal protein SP-10 isoform d precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acrosomal protein SP-10

  • sperm protein 10

ACRV1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACRV1 P26436 CISD2 Homo sapiens Q8N5K1
Y2H Pooling
32814053
Intra
ACRV1 P26436 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32814053
Intra
ACRV1 P26436 CISD2 Homo sapiens Q8N5K1
Y2H Array
32814053
Intra
ACRV1 P26436 PPT1 Homo sapiens P50897
Validated Y2H
32814053
Intra
ACRV1 P26436 PPT1 Homo sapiens P50897
Y2H Array
32814053
Intra
ACRV1 P26436 PPT1 Homo sapiens P50897
Y2H Pooling
32814053
Intra
ACRV1 P26436 PANK2 Homo sapiens Q9BZ23-2
Y2H Pooling
32814053
Intra
ACRV1 P26436 PANK2 Homo sapiens Q9BZ23-2
Validated Y2H
32814053
Intra
ACRV1 P26436 PANK2 Homo sapiens Q9BZ23-2
Y2H Array
32814053
Intra
ACRV1 P26436 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
ACRV1 P26436 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
ACRV1 P26436 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACRV1 Proteins

Cat. No. Product Name Accession Purity
HY-P71139 SP-10/ACRV1 Protein, Human (HEK293, C-His) P26436-1 (Q22-I265) ≥ 95%, as determined by reducing SDS-PAGE.

ACRV1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82111 ACRV1 Antibody (YA1856) WB Human
HY-P84219 ACRV1 Antibody (YA3916) IHC-P, FC, ELISA Human
HY-P84219A ACRV1 Antibody (YA3916)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Byssinosis

  • Flax-Dressers' Disease

  • Cotton Mill Fever

  • Stripper'S Asthma

  • Monday Morning Fever

  • Cotton Workers' Lung Disease

  • Cotton-Dust Asthma

  • Mill Fever

  • Lung Fibrosis With Byssinosis

  • Airway Disease Due To Cotton Dust

  • Respiratory Tract Disorder Due To Cotton Dust

  • Strippers' Disease

  • Flax-Dressers' Disorder

  • Strippers' Asthma
Hordeolum

  • Stye

  • Boil Of Eyelid

  • Furuncle Of Eyelid

  • Hordeolum Externum
Spastic Hemiplegia

  • Spastic Hemiplegic Cerebral Palsy

  • Hemiplegic Cerebral Palsy

  • Congenital Hemiplegia

  • Hemiplegic Infantile Cerebral Palsy

  • Cerebral Palsy Spastic Hemiplegic

  • Spastic Hemiplegia Cerebral Palsy

  • Hemiplegia, Spastic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00195 ACRV1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20359 Acrv1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26868 Acrv1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ACRV1 VGNC VGNC:37528
Bos taurus ACRV1 VGNC VGNC:25559
Rattus norvegicus ACRV1 RGD RGD:620153
Mus musculus ACRV1 MGD MGI:104590
Macaca mulatta ACRV1 VGNC VGNC:99536
Others ACRV1 NCBI