MAPK13 - mitogen-activated protein kinase 13 Gene

Homo sapiens

Also known as SAPK4; PRKM13; MAPK 13; MAPK-13; p38delta

Gene ID: 5603 | Gene type: protein coding

About MAPK13

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:36,130,513-36,144,521 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues and 19 paralogues. Broad expression in skin (RPKM 21.7), small intestine (RPKM 17.1) and 22 other tissues.

Summary

This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

MAPK13 Products(2)

mRNA	Protein	Name
NR_072996.2
NM_002754.5	NP_002745.1	mitogen-activated protein kinase 13

MAPK13 Protein Structure

Pkinase

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 13

MAP kinase 13	MAP kinase p38 delta
mitogen-activated protein kinase p38 delta	stress-activated protein kinase 4

Recombinant MAPK13 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73334	p38 delta/MAPK13 Protein, Human (sf9, GST)	O15264 (M1-L365)	≥95%

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18850	MAPK13-IN-1	Inhibitor	98.93%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAPK13	VGNC	VGNC:42994
Mus musculus	MAPK13	MGD	MGI:1346864
Rattus norvegicus	MAPK13	RGD	RGD:3045
Macaca mulatta	MAPK13	VGNC	VGNC:74644
Felis catus	MAPK13	VGNC	VGNC:68166
Bos taurus	MAPK13	VGNC	VGNC:50213
Others	MAPK13	NCBI