MAPK13 - mitogen-activated protein kinase 13 Gene

Also Known as SAPK4; PRKM13; MAPK 13; MAPK-13; p38delta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5603

About MAPK13

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:36,130,513-36,144,521 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues and 19 paralogues. Broad expression in skin (RPKM 21.7), small intestine (RPKM 17.1) and 22 other tissues.

Summary

This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

MAPK13 Products (2)

mRNA Protein Name
NR_072996.2
NM_002754.5 NP_002745.1 mitogen-activated protein kinase 13

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables MAP kinase activity IDA
IDA: Inferred from direct assay
9218798 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19135240 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12244047 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to UV IDA
IDA: Inferred from direct assay
9218798 GOA
involved in cellular response to anisomycin IDA
IDA: Inferred from direct assay
9218798 GOA
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
9218798 GOA
involved in cellular response to interleukin-1 IDA
IDA: Inferred from direct assay
9218798 GOA
involved in cellular response to sodium arsenite IDA
IDA: Inferred from direct assay
9218798 GOA
involved in cellular response to sorbitol IDA
IDA: Inferred from direct assay
9218798 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
15850461 GOA
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
19279008 GOA
involved in response to osmotic stress IDA
IDA: Inferred from direct assay
9731215 GOA
involved in stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
9218798 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK13 Protein Structure

Pkinase

Pkinase: Protein kinase domain (29 - 308)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 13

  • MAP kinase 13

  • MAP kinase p38 delta

  • mitogen-activated protein kinase p38 delta

  • stress-activated protein kinase 4

MAPK13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAPK13 O15264 PRKD1 Homo sapiens Q15139
Anti Tag CoIP
19135240
Intra
MAPK13 O15264 PRKD1 Homo sapiens Q15139
Protein Kinase Assay
19135240
Intra
MAPK13 O15264 FPR1 Homo sapiens P21462
Anti Bait CoIP
22447027
Intra
MAPK13 O15264 POTEF Homo sapiens A5A3E0
Anti Tag CoIP
28514442
Intra
MAPK13 O15264 POTEF Homo sapiens A5A3E0
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPK13 Proteins

Cat. No. Product Name Accession Purity
HY-P73334 p38 delta/MAPK13 Protein, Human (Active, sf9, GST) O15264-1 (M1-L365) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18850 MAPK13-IN-1 Inhibitor 98.88% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MAPK13 VGNC VGNC:42994
Mus musculus MAPK13 MGD MGI:1346864
Rattus norvegicus MAPK13 RGD RGD:3045
Macaca mulatta MAPK13 VGNC VGNC:74644
Felis catus MAPK13 VGNC VGNC:68166
Bos taurus MAPK13 VGNC VGNC:50213
Others MAPK13 NCBI