Nupr1 - nuclear protein transcription regulator 1 Gene

Also Known as p8; Com1; 2310032H04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56312

Summary

Enables acetyltransferase activator activity and chromatin binding activity. Involved in several processes, including negative regulation of autophagy; negative regulation of type B pancreatic cell proliferation; and positive regulation of neuroinflammatory response. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of fibroblast proliferation; and skeletal muscle cell differentiation. Predicted to be located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; jaw; orbito-sphenoid; pancreas; and sensory organ. Used to study Sertoli cell-only syndrome. Orthologous to human NUPR1 (nuclear protein 1, transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]

Nupr1 Products (1)

mRNA Protein Name
NM_019738.1 NP_062712.1 nuclear protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables acetyltransferase activator activity IMP
IMP: Inferred from mutant phenotype
19723804 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
19723804 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19723804 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within acute inflammatory response IMP
IMP: Inferred from mutant phenotype
14660681 MGI
acts upstream of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
11896600 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
11896600 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
11896600 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
18495683 MGI
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
20181828 MGI
acts upstream of or within negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
19723804 MGI
involved in negative regulation of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
27451286 MGI
involved in negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
27451286 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
11896600 MGI
involved in negative regulation of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
23900510 MGI
acts upstream of or within positive regulation of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
11896600 MGI
involved in positive regulation of neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
16374777 MGI
acts upstream of or within positive regulation of protein modification process IMP
IMP: Inferred from mutant phenotype
19723804 MGI
acts upstream of or within protein acetylation IMP
IMP: Inferred from mutant phenotype
19723804 MGI
acts upstream of or within protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
19723804 MGI
acts upstream of or within regulation of female gonad development IMP
IMP: Inferred from mutant phenotype
18495683 MGI
acts upstream of or within response to toxic substance IMP
IMP: Inferred from mutant phenotype
14660681 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19723804 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear protein 1

  • nuclear transcriptional regulator protein 1

  • protein p8

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0532A Trifluoperazine dihydrochloride 99.98% Unkown
HY-B0532 Trifluoperazine 99.87% Unkown
HY-B0532B Trifluoperazine dimaleate / Unkown

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111838A ZZW-115 hydrochloride Inducer 98.09% Unkown
HY-111838 ZZW-115 Activator 99.88% Unkown
HY-RS09702 NUPR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0532AS Trifluoperazine-d3 dihydrochloride / Unkown
HY-RS17469 Nupr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23927 Nupr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nupr1 NCBI NCBI:26471