Rbx1 - ring-box 1 Gene

Also Known as ROC1; 1500002P15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56438

Summary

Predicted to enable cullin family protein binding activity; ubiquitin protein Ligase binding activity; and ubiquitin-like protein Ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Acts upstream of or within protein K48-linked ubiquitination; protein catabolic process; and protein monoubiquitination. Located in cytosol. Part of SCF ubiquitin Ligase complex. Is expressed in several structures, including genitourinary system. Orthologous to human RBX1 (ring-box 1). [provided by Alliance of Genome Resources, Apr 2022]

Rbx1 Products (1)

mRNA Protein Name
NM_019712.3 NP_062686.1 E3 ubiquitin-protein ligase RBX1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14960280 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA damage response EXP
EXP: Inferred from Experiment
22118460 MGI
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
12140560 MGI
involved in cellular response to UV EXP
EXP: Inferred from Experiment
22118460 MGI
acts upstream of or within protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29593216 MGI
acts upstream of or within protein catabolic process IMP
IMP: Inferred from mutant phenotype
15601820 MGI
acts upstream of or within protein monoubiquitination IGI
IGI: Inferred from genetic interaction
21343341 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
12140560 MGI
Cellular Component GO Annotation Evidence References Source
part of Cul4A-RING E3 ubiquitin ligase complex EXP
EXP: Inferred from Experiment
22118460 MGI
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
12140560 MGI
part of SCF ubiquitin ligase complex IPI
IPI: Inferred from physical interaction
16880526 MGI
located in cytosol IDA
IDA: Inferred from direct assay
12140560 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RBX1

  • E3 ubiquitin-protein transferase RBX1

  • RING finger protein 75

  • ring-box protein 1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14658 Thalidomide Inducer 99.98% Yes

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14571 E7820 Inhibitor 99.26% Unkown
HY-RS11776 RBX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-14658S Thalidomide-d4 Inducer 98.71% Unkown
HY-162240 SJH1-51B Degrader / Unkown
HY-182063 Z226407860 Inhibitor / Unkown
HY-RS18150 Rbx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24625 Rbx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rbx1 NCBI NCBI:9978