PSMD10 - proteasome 26S subunit, non-ATPase 10 Gene

Homo sapiens

Also known as p28; p28(GANK); dJ889N15.2

Gene ID: 5716 | Gene type: protein coding

About PSMD10

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:108,084,207-108,091,542 (from NCBI)

This gene has 7 transcripts (splice variants), 225 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 23.6), thyroid (RPKM 20.0) and 25 other tissues.

Summary

This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S Proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]

PSMD10 Products(2)

mRNA	Protein	Name
NM_002814.4	NP_002805.1	26S proteasome non-ATPase regulatory subunit 10 isoform 1
NM_170750.3	NP_736606.1	26S proteasome non-ATPase regulatory subunit 10 isoform 2

PSMD10 Protein Structure

Ank_2

Ank

Ank_2

0
100
200
226 a.a.

Protein Preferred Names

Protein Names

26S proteasome non-ATPase regulatory subunit 10

26S proteasome regulatory subunit p28

Recombinant PSMD10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70213	Gankyrin/PSMD10 Protein, Human	O75832 (M1-G226)	≥95%

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Uterine Corpus Sarcoma

Sarcoma Of Corpus Uteri	Sarcoma Of Uterus
Sarcoma Of The Corpus Uteri	Uterine Sarcoma
Sarcoma, Nos Of Uterus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11318	PSMD10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PSMD10	VGNC	VGNC:97572
Canis familiaris	PSMD10	VGNC	VGNC:45106
Macaca mulatta	PSMD10	VGNC	VGNC:103851
Mus musculus	PSMD10	MGD	MGI:1858898
Rattus norvegicus	PSMD10	RGD	RGD:620350
Others	PSMD10	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.